CAS: 850-52-2; Altrenogest

上下游产品

ethylene deltenone 17β-hydroxy-17α-propenylestrone-3-one-5,10-diene Trendione allylmagnesium bromide

在 四氯苯醌体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,以77.3%的收率获得产物四烯雌酮
参考文献:一种烯丙孕素的高效合成方法
标题:一种烯丙孕素的高效合成方法
摘要:本发明涉及一种烯丙孕素的高效合成方法,属于兽药技术领域.本发明的合成方法包括以下步骤:S1,以雌甾4,9‑二烯‑3,17‑二酮(Sm)为起始原料,在二异丙基氨基锂(Lda)和三甲基氯硅烷((Ch3)3Sicl)的作用下,反应生成中间体xy‑1;s2,将中间体xy‑1与烯丙基溴化镁发生格式反应得到中间体xy‑2;s3,将中间体xy‑2在脱保护剂的作用下进行双键重排和脱保护基反应得到烯丙孕素粗品,经过重结晶纯化后得到高纯度烯丙孕素.本发明制得的烯丙孕素产品收率高,产品纯度高;整个工艺路线没有用到剧毒的反应,且各种试剂相对廉价易得,易于大规模放大.

专利信息

专利号:US-7507380-B2
优先权日:2004-03-19
标 题 :Microchemical nanofactories
发明人：CHANG CHIH-HUNG; PAUL BRIAN KEVIN; REMCHO VINCENT THOMAS
权利人:OREGON STATE
摘要:Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.

专利号:US-2012298037-A1
优先权日:2006-09-01
标 题:Microchemical nanofactories
发明人：PAUL BRIAN KEVIN; CHANG CHIH-HUNG; REMCHO VINCENT THOMAS
权利人:PAUL BRIAN KEVIN; CHANG CHIH-HUNG; REMCHO VINCENT THOMAS; STATE UNIVERSITY; OREGON STATE
摘要:Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

专利号:CN-109232700-B
优先权日:2018-09-17
标题:A kind of efficient synthesis method of alloprogest

专利号:CN-109232700-A
优先权日:2018-09-17
标题:A kind of efficient synthesis method of alloprogest