CAS: 90764-90-2; 5-Amino-3-Methyl-1H-Indazole

上下游产品

3-甲基-5-硝基-1H-吲唑 3-Methyl-5-Nitro-1H-Indazole 40621-84-9
3-甲基-1H-吲唑 3-Methyl-1H-Indazole 3176-62-3

2-氯-5-硝基苯乙酮置于palladium On Activated Charcoal 氢气,肼体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.0H,反应生成 3-甲基-1H-吲唑-5-胺
参考文献:Structure-Based Design,Synthesis,And Antimicrobial Activity Of Indazole-Derived Sah/mta Nucleosidase Inhibitors
标题:Structure-Based Design,Synthesis,And Antimicrobial Activity Of Indazole-Derived Sah/mta Nucleosidase Inhibitors
摘要:The Structure-Based Design,Synthesis,And Biological Activity Of A Novel Indazole-Containing Inhibitor Series For S-Adenosyl Homocysteine/methylthioadenosine (Sah/mta) Nucleosidase Are Described. Use Of 5-Aminoindazole As The Core Scaffold Provided A Structure-Guided Series Of Low Nanomolar Inhibitors With Broad-Spectrum Antimicrobial Activity. The Implementation Of Structure-Based Methodologies Provided A 6000-Fold Increase In Potency Over A Short Timeline (Several Months) And An Economy Of Synthesized Compounds.
DOI:10.1021/jm0302039

专利信息

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.