CAS: 913614-15-0; 4-(4-(Benzo[b]Thiophen-4-yl)Piperazin-1-yl)Butan-1-Ol

该化合物是二丙烯的一种结构上经过修改的衍生物,旨在增强药理特性,同时保持治疗效力;该化合物的特点是消除五醇基动物,这可以提高代谢稳定性,减少目标外的相互作用;其优化结构保持了血清素和多巴胺受体的高亲和性,支持其在...

英文名称4-(4-(Benzo[b]Thiophen-4-yl)Piperazin-1-yl)Butan-1-Ol
中文名称依匹哌唑杂质6
IUPAC名称4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butan-1-ol
其它别名Brexpiprazole Desquinolinonyl Impurity; 1-Piperazinebutanol, 4-Benzo[b]Thien-4-Yl-; Epipiprazole Impurity 6; 4-[4-(Benzothiophen-4-yl)Piperazin-1-Yl]Butan-1-Ol; 4-(4-Benzo[b]Thiophen-4-Yl-Piperazin-1-yl)Butan-1-Ol; Bripiprazole Impurity 14
CAS编号913614-15-0
分子式:C16H22N2OS
分子量:290.43
产品CID: 1949076
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: PHIXUCQCQUCNGS-UHFFFAOYSA-N
InChI=1S/C16H22N2OS/c19-12-2-1-7-17-8-10-18(11-9-17)15-4-3-5-16-14(15)6-13-20-16/h3-6,13,19H,1-2,7-12H2…
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数5.0

MSDS等安全信息

上下游产品

4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl acetate 4-bromobenzo[b]thiophene 1-benzo[b]thiophen-4-ylpiperazine hydr°Chloride 1-(benzo[b]thiophen-4-yl)piperazine hydr°Chloride

合成工艺路线路线简述

846038-18-4 = 913614-15-0
反应条件:1.1 Reagents: Hydrogen Catalysts: Rhodium(1+),[2,8-Bis(1,1-Dimethylethyl)-4,5,6,10,11,12-Hexahydro-4,6,10,12-Tetr... Solvents: Tetrahydrofuran; 18 H,80 Bar,150 °C
标题:Coordination Assembly Enables Highly Selective Catalytic Hydroaminomethylation Of Olefins
作者:Qian,Chun; Zheng,Qingshu; Chen,Jie; Tu,Bo; Tu,Tao
参考文献:Green Chemistry 日期:2023 卷标:25(4) 页码:1368-1379

4-溴苯并[b]噻吩置于tris-(Dibenzylideneacetone)Dipalladium(0),(R)-2,2'-Bis(Diphenylphosphanyl)-1,1'-Binaphthyl 盐酸,甲醇,水,Potassium Carbonate,Sodium T-Butanolate体系中,用甲醇,水,N,N-二甲基甲酰胺,甲苯作为反应溶剂,化学反应 9.0H,反应生成依匹哌唑杂质6
参考文献:Wo2006/112464
标题:Wo2006/112464