专利号:US-6417399-B1 优先权日:1997-01-14 标 题:Amelioration of neurological disorders by the administration of (2R),(3S), and/or (2S),3(S) stereoisomers of valnoctamide 发明人:BIALER MEIR; YAGEN BORIS; SPIEGELSTEIN OFER; ROEDER MICHAEL; SCHURIG VOLKER 权利人:YISSUM RES DEV CO 摘要:The present invention generally relates to the individual stereoisomers of the drug valnoctamide (a mixture of four stereoisomer kinds, VCD-valmethamide or 2-ethyl-3-methyl pentanamide) useful in treatment of neurological and psychotic disorders such as different kinds of epilepsy and affective disorders, and useful as tranquilizers and to treat pain, and to pharmaceutical compositions containing, as an active ingredient, these stereoisomers. The present invention further relates to a method for stereoselective separation and quantification of the four stereoisomers from a racemic mixture of VCD or plasma of patients treated with the racemic drug. The present invention further relates to a unique method for the synthesis of the individual stereoisomers.
专利号:US-11597741-B2 优先权日:2020-08-13 标 题 :Processes and materials for the synthesis of sugar esters found in natural tobacco 发明人:XING CHENYUE 权利人:MYST LABS INC 摘要:A process and materials method for making a glucose tetraester may include reacting glucose with a carboxylic acid to create a glucose pentaester. The glucose pentaester was reacted with a basic reagent to create a glucose tetraester. Glucose was reacted with a carboxylic acid anhydride in the presence of 4-dimethylaminopyridine to create a glucose pentaester product. The glucose pentaester reaction product was separated. The glucose pentaester reaction product was reacted with a basic reagent, wherein the reaction steps may take place at a temperature of about 0° C. to about 60° C. and about ambient pressure, wherein the ratio of the carboxylic acid to the glucose was from about 5:1 to about 50:1, and wherein the ratio of the glucose pentaester to the basic reagent was from about 1:50 to about 1:150.
专利号:US-9481898-B2 优先权日:2010-01-15 标题 :Electro-autotrophic synthesis of higher alcohols 发明人:LIAO JAMES C; CHO KWANG MYUNG 权利人:UNIV CALIFORNIA 摘要:The disclosure provides a process that converts CO 2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H 2 or formate. H 2 can be derived from electrolysis of water. Formate can be generated by electrochemical reduction of CO 2 . After delivering the reducing power in the cell, formate becomes CO 2 and recycles back. Therefore, the biological CO 2 fixation process can occur in the dark.
专利号:WO-2022229983-A1 优先权日:2021-04-29 标题:Sugar esters and sugar alcohol esters of short chain fatty acids and compositions thereof 发明人:KANUMURU RAHUL RAJU; SHAJI GEORGE KOCHUMALAYIL; ANINDYA SIL; SURANENI RAVIKUMAR; GARUDADRI LAKSHMI PRASANNA KUMAR 权利人:FERTIS INDIA PVT LTD 摘要:The present invention discloses compositions comprising sugar esters and sugar alcohol esters of short chain fatty acids and their use in pest management. These compositions possess antiviral, antimicrobial, insecticidal, pesticidal and herbicidal properties and their potential use in controlling, Lepidoptera, Hemiptera and Thysanoptera insects, Tomato spotted wilt viruses, Tobacco mosaic viruses. The present invention also dicloses compositions of sugar esters and sugar alcohol esters of short chain fatty acids as potential agents for treating oral and dermatological problems of microbial origin. The present invention further discloses the synthesis of novel sugar esters and sugar alcohol esters of short chain fatty acids.
专利号:US-3708547-A 优先权日:1969-09-02 标 题 :Synthesis of(10)-annulenes 发明人:NELSON P; UNTCH K 权利人:SYNTEX CORP 摘要:NEW PROCESS FOR PREPARING (10)-ANNULENE COMPOUNDS WHICH ARE USEFUL AS ESTROGENIC, ANTI-INFLAMMATORY, AND ANTI-FERTILITY AGENTS. THE PROCESS UTILIZES THE STEPS OF ADDING A METHANO, DICHLOROMETHANO, OR DIFLUOROMETHAO GROUP ACROSS THE C-9,10 DOUBLE BOND OF A 1,4,5,8-TETRAHYDRONAPHTHALENE TO THE CORRESPONDIG 9,10-BRIDGED-1,45,8,9,10-HEXAHYDRONAPHTHLENE AND TREATING THE LATTER WITH A BENZOQUINONE TO THE CORRESPONDING 1,6-BRIDGED(10)-ANNULENE PRODUCT. THE PREPARATINS OF 1,6-METHANO(10)-ANNULENE, 1,6-DICHLOROMETHANO-(10)-ANNULENE, AND 1,6-DIFLUOROMETHANE-(10)-ANNULENE ARE ILLUSTRATED AS REPRESENSTATIVE OF THE PROCESS.
专利号:WO-9722598-A1 优先权日:1995-12-15 标 题 :Method of making (s-(r*,r*))-3-methyl-2-(3-oxo-3h-benzo(d)isothiazol-2-yl)pentanoic acid and (s-(r*,r*)), l-2-(2-(2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl)benzoyl-amino)-3-methylpentanoic acid 发明人:FIORE PHILLIP; PULS TIMOTHY P; WALKER JONATHAN 权利人:WARNER LAMBERT CO; FIORE PHILLIP; PULS TIMOTHY P; WALKER JONATHAN 摘要:The present application discloses a synthesis of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]-isothiazol-2-yl)pentanoic acid and [S-(R*,R*)], L-2-{2-[2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl]-benzoylamino}-3-methylpentanoic acid.
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