CAS: 1201924-32-4; 6-Chloro-3-Methylpicolinic Acid

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CAS号878207-92-2 6-氯-3-甲基-2-吡啶羧酸甲酯 | CAS号1201924-31-3 6-氯-3-甲基-2-吡啶甲腈... | CAS号20970-75-6 2-氰基-3-甲基吡啶 | CAS号159727-88-5 2-氰基-3-甲基吡啶1-氧化物 | CAS号878207-92-2 6-氯-3-甲基-2-吡啶羧酸甲酯

3-甲基-2-吡啶甲酸置于氯化亚砜,水,N,N-二甲基甲酰胺,间氯过氧苯甲酸,Lithium Hydroxide,三氯氧磷体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 48.0H,反应生成6-氯-3-甲基吡啶-2-甲酸
参考文献: Heteroaryl Compounds As Inhibitors Of Necrosis,Composition And Application Thereof[fr] Composés Hétéroaryliques Utilisés Comme Inhibiteurs De La Nécrose,Composition Et Application Associées
标题: Heteroaryl Compounds As Inhibitors Of Necrosis,Composition And Application Thereof[fr] Composés Hétéroaryliques Utilisés Comme Inhibiteurs De La Nécrose,Composition Et Application Associées
摘要:本公开提供了公式(i),(ia)和(ib)的杂环芳基化合物,它们的制备方法,含有它们的药物组合物,以及它们在治疗因坏死引起或相关的疾病和疾病中的用途. (公式(i)).

专利信息

专利号:US-9364482-B2
优先权日:2013-06-24
标 题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; ZORN NICOLAS; DANG QUN; MCCOMAS CASEY C; PENG XUANJIA; LI PENG; SOLL RICHARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)