CAS: 132388-59-1; Fmoc-Asn(Trt)-Oh

上下游产品

CAS号76-84-6 三苯基甲醇 | CAS号71989-16-7 Fm°C-L-天冬酰胺 | CAS号107-06-2 1,2-二氯乙烷 | CAS号132388-57-9 N-苄氧羰基-N'-三苯甲基-... | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号132388-58-0 N'-(三苯甲基)-L-天冬酰胺 | CAS号198543-08-7 Fm°C-Asn(Trt)-ol | CAS号71989-16-7 Fm°C-L-天冬酰胺 | CAS号132388-58-0 N'-(三苯甲基)-L-天冬酰胺 | CAS号132388-64-8 L-天门冬二氨酸

三苯基甲醇置于palladium On Activated Charcoal 硫酸,氢气,乙酸酐体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,反应生成Fmoc-N-三苯甲基-L-天冬酰胺
参考文献:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
标题:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
摘要:羧酰胺官能团可以通过在冰醋酸中与三苯甲醇和乙酸酐进行酸催化反应来三苯甲基化.天冬酰胺和谷氨酰胺的ω-三苯甲基可被tfa裂解,但对水溶液中的强无机酸以及亲核试剂和碱稳定.在肽合成中,它非常适合与叔丁基类型的侧链保护结合使用.
Doi:10.1016/s0040-4039(00)74872-6

专利信息

专利号:US-2023242581-A1
优先权日:2020-06-17
标题:Synthesis of a guanylate cyclase agonist by fragments based approach
发明人：SAMBASIVAM GANESH; KASTURCHAND GODHA ATUL; VENKATA BHAGYARAJ ARETI; ANNADURAI SATHYA; VEERANJANEYULU AVULA; VASANTRAO GADAKH AMOL; S JADHAV DIPAK
权利人:ANTHEM BIOSCIENCES PRIVATE LTD
摘要:The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.

专利号:US-2024067694-A1
优先权日:2021-01-04
标 题:Synthesis of teduglutide
发明人：GANGA RAMU VASANTHAKUMAR; PATIL NITIN; SUVARNA DEEPA SHANKAR
权利人:BIOCON LTD
摘要:The present invention provides for novel synthetic approach of solid phase synthesis of peptides with C-terminal Aspartic acid by anchoring the side chain carboxylic group of aspartic acid to the solid support to avoid the formation of various impurities and thus resulting in higher yield and ease the purification process. The present invention further provides the usage of free amino acids and reducing agents as antioxidants in the cleavage cocktail to negate the formation of oxidative impurities formed during the global cleavage and isolation of the peptide from solid support.

专利号:EP-1960423-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-12251674-B2
优先权日:2012-11-14
标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
权利人:VIBRANT HOLDINGS LLC
摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

专利号:US-2024287128-A1
优先权日:2020-11-17
标题:Extremely fast solid phase synthesis
发明人：GILON CHAIM; HUREVICH MATTAN; BENTOLILA MOSHE; ALSHANSKI ISRAEL; NAOUM JOHNNY
权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:The present disclosure generally relates to the field of solid phase synthesis and methods for synthesizing peptides and employing solid phase synthesis.