CAS: 14338-36-4; 3-Aminophenylacetic Acid

上下游产品

CAS号1877-73-2 3-硝基苯乙酸 | CAS号621-50-1 间硝基苯乙腈 | CAS号619-25-0 3-硝基苯甲醇 | CAS号619-23-8 间硝基氯化苄 | CAS号89894-59-7 1,1,1-trichloro... | CAS号2028-76-4 3-nitrobenzened... | CAS号7647-01-0 盐酸 | CAS号1877-73-2 3-硝基苯乙酸 | CAS号1878-69-9 3-碘苯乙酸 | CAS号1878-71-3 3-氰基-苯乙酸 | CAS号1878-65-5 3-氯苯乙酸 | CAS号63271-86-3 2-(3-MERCAPTOPH... | CAS号52913-11-8 3-氨基苯乙酸甲酯 | CAS号621-37-4 3-羟基苯乙酸 | CAS号52273-77-5 2-(3-氨基苯基)乙醇 | CAS号129743-47-1 2-(3-氨基苯)乙酰胺 | CAS号123036-51-1 N-B°C-3-氨基苯乙酸

3-硝基苯乙酸置于palladium On Activated Charcoal 氢气体系中,用 乙醇 用作溶剂,以74%的收率获得3-氨基苯乙酸
参考文献:N-苯基-N'-(2-氯乙基)脲(ceus)作为潜在的抗肿瘤药.第3部分:羰基在与秋水仙碱结合位点的共价结合中的作用.
标题:N-苯基-N'-(2-氯乙基)脲(ceus)作为潜在的抗肿瘤药.第3部分:羰基在与秋水仙碱结合位点的共价结合中的作用.
摘要:在开发n-苯基-N'-(2-氯乙基)脲(ceus)作为潜在的抗肿瘤药的过程中,我们研究了ceu芳环的羰基取代链对它们与秋水仙碱的共价结合的影响.结合位点(c-Bs).在这项研究中,我们发现在ω-位被甲基或甲基酮基取代的ceu,5E,5F,8E和8F对ht-29,M21和mcf-7肿瘤表现出显着的抗增殖活性细胞.Sds-Page分析和细胞周期分析证实5E,5F,8E和8F与c-Bs共价结合,并使细胞分裂停滞在g(2)/ M期.令人惊讶地,ω-羧基,ω-乙基酯或ω-酰胺的存在显着降低了抗增殖活性和对β-微管蛋白的特异性.
Doi:10.1016/j.Bmc.2007.10.078

专利信息

专利号:US-4780504-A
优先权日:1985-06-20
标 题 :Supports useful in solid phase synthesis of oligonucleotides
发明人：BUENDIA JEAN; NIERAT JEANINE
权利人:ROUSSEL UCLAF
摘要:Novel supports useful in solid phase synthesis of oligonucleotides of the formula I +TR wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

专利号:WO-9426779-A1
优先权日:1993-05-13
标 题 :PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS
发明人：MADUSKUIE THOMAS PETER JR
权利人:DU PONT MERCK PHARMA
摘要:This invention provides processes and intermediates for the synthesis of platelet glycoprotein IIb/IIIa inhibitors of formula (I).

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:EP-0206913-B1
优先权日:1985-06-20
标题:Supports, the preparation of these supports, intermediates obtained, their use in the synthesis of oligonucleotides, and nucleosides and oligonucleotides linked to the supports

专利号:WO-9811438-A1
优先权日:1996-09-13
标题 :Synthesis of quinazolinone libraries and derivatives thereof