CAS: 143782-23-4; 4-Isothiocyanato-2-(Trifluoromethyl)Benzonitrile

相似化合物

654-70-6 654-70-6 354814-19-0

上下游产品

thiophosgene 4-amino-2-trifluoromethylbenzonitrile 1,1'-Thi°Carbonyldiimidazole 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]°Ct-5-yl]phenyl}butanoic acid enzalutamide (4S)-2-(4-cyano-3-(trifluoromethyl)phenylimino)-4-(2-butyl)-1,3-thiazolidine tert-butyl 3-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propylsulfonyl(methyl)carbamate

4-氨基-2-三氟甲基苯甲腈置于四磷十氧化物,水,Sodium Hydroxide体系中,用 乙酸乙酯,氯苯 用作溶剂,化学反应 30.0H,反应生成4-异硫代氰酰基-2-(三氟甲基)苯甲腈
参考文献:一种绿色环保的4-异硫代氰酰基-2-(三氟甲基)苯甲腈的制备方法
标题:一种绿色环保的4-异硫代氰酰基-2-(三氟甲基)苯甲腈的制备方法
摘要:本发明属于有机合成技术领域,更具体地涉及一种绿色环保的4‑异硫代氰酰基‑2‑(三氟甲基)苯甲腈的制备方法,包括三步:缩合反应,水解反应和脱氨反应.本发明采用乙酸乙酯代替有毒溶剂进行缩合反应,安全环保,同时还可回收再利用,降低成本;水解后利用甲苯打浆可有效提高1‑(4‑氰基‑3‑(三氟甲基)苯基)硫脲的精度和纯度,收率高;通过吸氨试剂吸收反应产生的氨气,可提高反应速率和收率;该制备方法采用三步合成,方法简单,操作安全环保,产品收率和纯度高.

专利信息

专利号:US-9174943-B2
优先权日:2010-02-24
标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
发明人：JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT
权利人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT; MEDIVATION PROSTATE THERAPEUTICS INC
摘要:Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

专利号:US-10626091-B2
优先权日:2014-10-01
标 题 :Process for the preparation of enzalutamide
发明人：CHIVUKULA KAMESWAR RAO; KARUTURI VEERA VENKATESWARA RAO; BENDA SRINIVAS; ANKE RAMACHANDRA; GAJULA DHARMAPURI; MOTURU VENKATA RAMA KRISHNA MURTHY; INDUKURI VENKATA SUNIL KUMAR; GORANTLA SEETA RAMA ANJANEYULU; CHAVA SATYANARAYANA
权利人:LAURUS LABS LTD
摘要:The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.

专利号:US-2017190670-A1
优先权日:2014-07-11
标题:Improved process for the preparation of enzalutamide
发明人：HIRPARA SANJAY; SHRAWAT VIMAL KUMAR; POTHURAJU RAJU; TRIPATHI CHANDRESH KUMAR; AKSHAYKANT CHATURVEDI
权利人:SHILPA MEDICARE LTD
摘要:The present application relates to an improved process for preparation of Enzalutamide (I). n n n n n n n n n n The present application also relates to an improved process for the preparation of substantially pure Enzalutamide (I) having purity of greater than 99.5%. n The present application also relates to a novel process for the preparation of Enzalutamide intermediate useful in the industrially viable synthesis of Enzalutamide.

专利号:KR-101514659-B1
优先权日:2010-02-24
标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

专利号:JP-2013520519-A
优先权日:2010-02-24
标题:Process for the synthesis of diarylthiohydantoin compounds and diarylhydantoin compounds

专利号:ES-2880354-T3
优先权日:2010-02-24
标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds