1,10-癸二醇置于potassium Permanganate,硫酸,氢溴酸体系中,化学反应生成 10-溴癸酸 参考文献:Synthesis And Biological Activities Of Acetylenic Fatty Acids And Their Esters 标题:Synthesis And Biological Activities Of Acetylenic Fatty Acids And Their Esters 摘要:通过邻硝基苯硒醚合成了 8 种末端炔脂肪酸:从 5-己炔酸到 12-十三炔酸及其甲基,乙基和异丙基酯.这些酸和酯对莴苣种子萌发和幼苗生长均有抑制作用.其作用效果依赖于炔链碳原子数.8-壬炔酸具有强烈的活性,其甲酯在所测试样品中活性最强.此外,这些酸具有抗菌活性,且随碳原子数的增加而增强. DOI:10.1246/bcsj.59.3535
专利号:US-9181292-B2 优先权日:2011-01-05 标题 :Methods for preparation of glycosphingolipids and uses thereof 发明人:LIANG PI-HUI 权利人:LIANG PI-HUI 摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
专利号:US-6175024-B1 优先权日:1999-03-03 标题 :Synthesis of functionalized esters 发明人:BOYLE JR WILLIAM J; REDDY INDIRA; QIAN ZHENRONG; SU HENG ERIC; RYCKMAN DAVID 权利人:ALLIED SIGNAL INC 摘要:A method of preparing an ester of a carboxylic acid functionalized with a moiety selected from the group consisting of halides, sulfonates, ethers, hydroxyl, amines, and aldehydes, said method comprising: (a) providing either a carboxylic acid having a vinyl group or an ester thereof; (b) functionalizing the vinyl carbon closest to the carboxyl group with said moiety, wherein said functionalizing comprises cleaving said vinyl group.
专利号:WO-2024035945-A1 优先权日:2022-08-12 标 题:Efficient synthesis of very-long-chain polyunsaturated fatty acids 发明人:Wade Alexander; GORUSUPUDI ARUNA; BERNSTEIN PAUL; RAINIER JON; RALLABANDI RAMESHU 权利人:UNIV UTAH RES FOUND 摘要:The rare non-dietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) uniquely found in retina and a few other tissues play a clinically significant role in retinal degeneration and development, but their physiological and interventional research has been hampered by scarcity of pure VLC-PUFAs. Disclosed herein are methods of making fatty acids, including VLC-PUFAs, and methods of using these fatty acids in, for example, treating eye disorders and supplementing the diet of a female subject who is pregnant, desiring to become pregnant, or lactating. Also disclosed are compositions containing fatty acids and methods of making and using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:WO-0051960-A1 优先权日:1999-03-03 标题 :Synthesis of functionalized esters
专利号:EP-4569012-A1 优先权日:2022-08-12 标题:Efficient synthesis of very-long-chain polyunsaturated fatty acids
专利号:WO-2024230844-A1 优先权日:2023-05-11 标 题:Cationic lipids and preparation method thereof 发明人:MASHIACH ROI 权利人:RIBOX THERAPEUTICS HK LTD 摘要:The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.
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合成参考文献
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