CAS: 526-83-0; 2,3-Dihydroxysuccinic Acid

相似化合物

147-73-9 133-37-9 13171-64-7

上下游产品

2,3-oxiranedicarboxylic acid tartaric aciddimethyl L-tartrate diethyl L-tartrate (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione (+)-Nicotine bitartrate

1,4-Dibromo-2,3-Dimethoxy-Succinaldehyde置于癸二酸二异辛酯,二甲基亚砜,Zinc Diacetate,Potassium Bromide体系中,用 正庚烷 作为反应溶剂,化学反应 4.33H,以98.3%的收率获得产物酒石酸
参考文献:2,3-二羟基丁二酸药物中间体合成方法
标题:2,3-二羟基丁二酸药物中间体合成方法
摘要:本发明公开了2,3‑二羟基丁二酸药物中间体合成方法,包括如下步骤:在反应容器中加入1,4‑二溴‑2,3‑二甲氧基‑丁二醛,庚烷溶液,控制搅拌速度170‑190Rpm,升高溶液温度至40‑46°C,加入水溶液,二甲基亚砜,在20‑40Min内分批次加入癸二酸二辛酯溶液,继续反应50‑80Min;升高温度至55‑62°C,加入溴化钾溶液,乙酸锌粉末,继续反应2‑3H,降低温度至10‑16°C,静置30‑50Min,加入硝酸钠溶液,溶液分层,分离出油层,用3‑己醇溶液洗涤30‑50Min,在环戊酸溶液中重结晶,脱水剂脱水,得成品2,3‑二羟基丁二酸.

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-9506095-B2
优先权日:2012-02-09
标 题:Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof
发明人：PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the enzymatic synthesis of the compound of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl group.n n Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-9994526-B2
优先权日:2011-04-04
标 题 :Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate
发明人：STIVANELLO MARIANO; HUBER FLORIAN ANTON MARTIN; RICCI ANTONIO
权利人:LUNDBECK PHARMACEUTICALS ITALY S P A
摘要:Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

专利号:US-9409153-B2
优先权日:2007-12-28
标题:Supported Mo—O—K—MexOy catalyst for the synthesis of methanethiol from high H2S-containing syngas
发明人：YANG YIQUAN; HAO YINGJUAN; CHEN AIPING; WANG QI; YANG LINGMEI; LI QIAOLING; DAI SHENJUN; FANG WEIPING; BARTH JAN-OLAF; WECKBECKER CHRISTOPH; HUTHMACHER KLAUS
权利人:YANG YIQUAN; HAO YINGJUAN; CHEN AIPING; WANG QI; YANG LINGMEI; LI QIAOLING; DAI SHENJUN; FANG WEIPING; BARTH JAN-OLAF; WECKBECKER CHRISTOPH; HUTHMACHER KLAUS; EVONIK DEGUSSA GMBH
摘要:This invention is related to a preparation method of a supported catalyst Mo—O—K-Me x O y for the synthesis of methanethiol from H 2 S-containing syngas. The catalyst comprises of an active component of Mo—O—K-based species, an active promoter and a support denoted as metal (or metals)-carrier. The support is prepared by electroless plating method in such a way that the metal or metals chosen are plated onto the surface of the carrier. Transition metal, especially Fe, Co or Ni are selected to be the plating metal, while SiO 2 , Al 2 O 3 or TiO 2 are selected to be carrier. The catalyst thus prepared is found to be efficient for the synthesis of methanethiol from H 2 S-containing syngasor carbon oxides/hydrogen mixtures, especially regarding a minor formation of the by-product CO 2 .

专利号:WO-2012001578-A1
优先权日:2010-06-29
标 题 :Single-step synthesis of iron oxide nanoparticles
发明人：BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN
权利人:KONINKL PHILIPS ELECTRONICS NV; BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN
摘要:The invention provides methods for the synthesis of iron oxide nanoparticles and the particles obtainable by these methods. The particles can be used as tracer materials for magnetic particle imaging and for Magnetic Particle Spectroscopy (MPS). The method for the synthesis of these particles comprises the steps: (i) dissolving at least one water-soluble iron salt and at least one water-soluble stabilizer in water to form a reaction batch, (ii) adding at least one base to the reaction batch to yield a pH of 10 to 13, and (iii) exposing the reaction batch to a reaction temperature T R for a defined period of time DT, wherein T R ≥ 110°C, to obtain the iron oxide nanoparticles.

专利号:US-5274117-A
优先权日:1990-01-22
标 题:Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
发明人：LEE THOMAS BING KIN DR; WONG GEORGE S K
权利人:HOECHST ROUSSEL PHARMA
摘要:A process for the stereoselective synthesis of [R]- and [S]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-indole-3-acetonitriles comprises reacting racemic and 5-alkoxy-substituted (+/-)-1,3-dimethyloxindoles with a halogenated acetonitrile in the presence of a substituted N-benzyl cinchoninium, quinidinium, cinchonidinium, or quininium catalyst. The resulting alkylated oxindoles can be converted to primary amines by catalytic reduction in the presence of hydrogen gas. One of the primary amines, such as enantiomers of 3-(2-aminoethyl)-1,3-dihydro-1,3-dimethyl-5-methoxy-2H-indol-2-one, can be enriched by contact with a chiral tartaric acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The product can be used in the synthesis of stereospecific forms of physostigmine and related compounds having pharmaceutical activity.