CAS: 66228-31-7; (R)-3,3-Dimethylbutan-2-Amine

上下游产品

(±)-3,3-二甲基-2-丁胺 2,2-Dimethyl-1-Methylpropylamine 3850-30-4

频哪酮置于palladium On Activated Charcoal B2H6-Thf,氢气,对甲苯磺酸体系中,用 四氢呋喃,乙醇,苯 作为反应溶剂,25.0 °C,101.33 Kpa 条件下,反应 82.0H,反应生成 (R)-3,3-二甲基-2-丁胺
参考文献:吡那地尔型氰基胍,硝基乙二胺,硫脲和尿素中钾通道开放的结构活性研究.
标题:吡那地尔型氰基胍,硝基乙二胺,硫脲和尿素中钾通道开放的结构活性研究.
摘要:通过同时测量自发收缩活性和刺激负载有86Rb +的大鼠门静脉的86Rb +外排,评估了吡那地尔型氰基胍,硝基乙二胺,硫脲和尿素的钾通道开放活性.这两种作用之间的非常好相关性表明,化合物的血管舒张活性直接归因于钾通道开放的增加.所得的定量体外数据已用于分析钾通道开放的结构-活性关系,从而可以根据涉及氢键受体元素,氢键供体元素的药效团合理化生物活性.和亲脂性结合基团.已经开发出了与吡那地尔相关的化合物与其钾通道受体结合的模型,并且已经合成和测试了设计用于测试该模型的化合物.质子平衡在确定化合物的氢键能力中起着基本作用,涉及受体的构象变化以解释不同化合物中亲脂性基团的手性识别差异.
DOI:10.1021/jm00090A025

专利信息

专利号:WO-2016005407-A1
优先权日:2014-07-07
标 题:One-pot synthesis of squaramides
发明人：MÃ?RQUEZ LÓPEZ MARÃ?A EUGENIA; ALEGRE REQUENA JUAN VICENTE; PÉREZ HERRERA RAQUEL
权利人:UNIV ZARAGOZA; CONSEJO SUPERIOR INVESTIGACION
摘要:The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purification steps, reduces costs and provides better yields as compared with those squaramides obtained through the traditional 'stop-and-go' approach. Moreover, the authors of the present invention herein demonstrate the efficiency of this one-pot process with the synthesis of three biologically active structures, improving in most of the cases the results of the previous stepwise syntheses.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-2024208920-A1
优先权日:2022-11-08
标 题:Synthesis of mda or its optically active (r)- or (s)-mda isomers
发明人：FAWAZ MAJED; MORRA NICHOLAS
权利人:EMPATHBIO INC
摘要:Provided herein is a process for the preparation of 3,4-methylenedioxyamphetamine, (R)-3,4-methylenedioxyamphetamine and (S)-3,4-methylenedioxyamphetamine.

专利号:US-9085511-B2
优先权日:2011-04-04
标题:Atropisomeric 1,8-bisphenolnapthalenes and their use in enantioselective recognition and asymmetric synthesis
发明人：WOLF CHRISTIAN; GHOSN MARWAN
权利人:WOLF CHRISTIAN; GHOSN MARWAN; UNIV GEORGETOWN
摘要:This invention related to atropisomeric 1,8-bisphenolnaphthalenes and derivatives thereof of the general formula (I): n nwhich are useful in resolution of enantiomers, enantioselective recognition and asymmetric synthesis.