CAS: 7119-95-1; 1-Nitropyrazole

相似化合物

35852-77-8 1789048-54-9 3994-46-5

上下游产品

CAS号288-13-1 吡唑 | CAS号4897-84-1 4-溴丁酸甲酯 | CAS号26621-44-3 5-硝基-1H-吡唑 | CAS号26621-44-3 5-硝基-1H-吡唑 | CAS号2075-46-9 4-硝基吡唑 | CAS号35852-77-8 1,4-dinitro-1H-...

吡唑置于硝酸,乙酸酐,溶剂黄146体系中,化学反应 0.5H,反应生成 1-硝基吡唑
参考文献:硝基吡唑结构和振动特性的实验和理论研究
标题:硝基吡唑结构和振动特性的实验和理论研究
摘要:摘要 我们报告了吡唑及其单硝基吡唑的结构和振动特性的理论和实验研究.吡唑,N-硝基吡唑,3-硝基吡唑和4-硝基吡唑的红外(ir)和拉曼光谱已在固态下记录.为了解释实验数据,在 Hf/6-311++g(D,P),B3P86/6-311++g(D,P),B3Lyp/6-311++g(D,P) 和 B3Lyp/aug-Cc-Pvdz 水平.实验和计算的结合使用允许对所有化合物的大多数观测到的条带进行可靠的分配.已发现计算的拉伸频率与实验频率非常一致.然而,与在 Hf/311++g(D,P),B3P86/311++g(D,P) 获得的值相比,在 B3Lyp/aug-Cc-Pvdz 水平计算的硝基吡唑的基本振动频率更高) 和 B3Lyp/311++g(D,P) 理论水平.键距和键角的差异仅限于硝基的扭曲,这在分子中表现出与平面性的最大偏差.
DOI:10.1016/j.Molstruc.2013.03.038

专利信息

专利号:US-11319291-B1
优先权日:2020-06-09
标 题:Continuous flow microfluidic process for synthesis of 3,4-dinitropyrazole
发明人：SCHROER THORSTEN G; LECROY GREGORY E; RODRIGUEZ MAYRA P; WANG SIDA; AGUILA MIGUEL
权利人:US GOV AIR FORCE; US AIR FORCE
摘要:Disclosed herein is a synthetic method, apparatus, and system for the continuous-flow synthesis of 3,4-dinitropyrazole from pyrazole in a microfluidic environment. This synthetic strategy consist of three (3) synthetic steps, including (1) N-nitration of pyrazole, (2) thermal rearrangement into 3-nitropyrazole, and (3) 4-nitration of 3-nitropyrazole. The current technique produces 3,4-dinitropyrazole in yields up to 85% in particular embodiments, in comparison to 40-50% yields demonstrated by the current state of-the-art batch process for large scale synthesis from pyrazole.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-5719283-A
优先权日:1990-06-20
标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
发明人：BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH
权利人:PFIZER
摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.

专利号:WO-2016147205-A1
优先权日:2015-03-13
标题 :Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
发明人：SURYAVANSHI GURUNATH MALLAPPA; SHELKE ANIL MARUTI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to novel substituted 3-spirophosphoryl, pyrazole-2-oxindoles of Formula (I) and its pharmaceutically acceptable salts, esters, ethers, isomers, stereoisomers, positional isomers and pplymorphs. The present invention further relates to one pot, one step process for the synthesis of spirophosphoiyl pyrazole oxindoles of Formula (I) with yield in the range of 70-85%.

专利号:US-11696954-B2
优先权日:2017-04-28
标题 :Synthesis of spherical nucleic acids using lipophilic moieties
发明人：KANG RICHARD; NALLAGATLA SUBBARAO; ANDERSON BART; KANDIMALLA EKAMBAR
权利人:EXICURE OPERATING COMPANY
摘要:Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein. Compositions of the SNA include discrete nanostructures that are not aggregated. Related methods are also described.

专利号:US-5663366-A
优先权日:1992-10-16
标 题:Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair
发明人：NEUNHOEFFER HANS; GERSTUNG STEFAN; CLAUSEN THOMAS; BALZER WOLFGANG R
权利人:WELLA AKTIENGESELLSCHAT
摘要:The subject matter of the present invention is directed to a process for producing 4,5-diaminopyrazole derivatives of the general formula (I) (I) where R1 and R2 independently designate hydrogen, a C1- to C6-alkyl radical or a C2- to C4-hydroxyalkyl radical, which can be used as dye precursors, for example for hair dyes, and to new pyrazole derivatives. When using the process according to the invention good yields of isomer-pure 4,5-diaminopyrazole derivatives of general formula (I) can be obtained.