CAS: 778611-64-6; 5-Bromo-2-Chloro-4-Methylpyridine

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55404-31-4 1000017-92-4 1060802-23-4

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2-amino-5-bromo-4-methylpyridine 5-bromo-2-chloropyridine methyl iodide 2-Amino-4-methylpyridine (2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid methyl ester 4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-N-(2-hydroxy-phenyl)-N-methyl-benzamide 4-(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid methyl ester 2-(4-((6-(6-chloro-4-methylpyridin-3-yl)-3-nitroquinolin-4-yl)methyl)phenyl)2-methylpropanenitrile

5-溴-2-羟基-4-甲基吡啶置于三氯氧磷体系中,化学反应 2.0H,以91%的收率获得产物2-氯-4-甲基-5-溴吡啶
参考文献:Large-Scale Solvent-Free Chlorination Of Hydroxy-Pyrimidines,-Pyridines,-Pyrazines And-Amides Using Equimolar Pocl3
标题:Large-Scale Solvent-Free Chlorination Of Hydroxy-Pyrimidines,-Pyridines,-Pyrazines And-Amides Using Equimolar Pocl3
摘要:使用等摩尔量的pocl3对羟基嘧啶进行氯化不仅是有效的,而且对许多其他底物,如2-羟基吡啶,喹唑啉或甚至酰胺也是如此.该过程是无溶剂的,涉及在密封反应器中高温加热,使用一当量的吡啶作为碱.它适用于大规模(多克级)批次制备.
DOI:10.3390/molecules17044533