CAS: 862189-95-5; 5-Ethyl-2-(5-((4-(2-Hydroxyethyl)Piperazin-1-yl)Sulfonyl)-2-Propoxyphenyl)-7-Propyl-3,5-Dihydro-4H-Pyrrolo[3,2-D]Pyrimidin-4-One

该化合物是一种主要用于处理立体机能障碍的选择性磷代谢酶5(PDE5)抑制剂,它的作用是通过增加血液流到胸腔洞中,促进性刺激的勃起.在结构上不同于其他PDE5抑制剂, Mirodenafil 表现出高度选择性和能动性,有助于其功效.它的药用动力学剖面包括快速吸收和相对短的半衰期,减少长期副作用的可能性.临床研究表明,在最小的不利作用下,如头痛或冲洗中,可以忍受.Mirodonafil的稳定性和生物利用率使它在治疗应用中成为一个可靠的选择,提供了效果和安全的平衡组合.

英文名称5-Ethyl-2-(5-((4-(2-Hydroxyethyl)Piperazin-1-yl)Sulfonyl)-2-Propoxyphenyl)-7-Propyl-3,5-Dihydro-4H-Pyrrolo[3,2-D]Pyrimidin-4-One
中文名称米罗那非
IUPAC名称5-ethyl-2-(5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)-2-propoxyphenyl)-7-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
其它别名5-Ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS编号862189-95-5
MFCD编号:MFCD09954134
FDA UNII编号:504G362H0H
分子式:C26H37N5O5S
分子量:531.68
产品CID: 1863184
同类组份化合物CAS862189-95-5 (free base)862189-96-6 (HCl)
产品分类原料药 → 其它化学药

相似结构搜索
InChIKey: MIJFNYMSCFYZNY-UHFFFAOYSA-N
MIJFNYMSCFYZNY-UHFFFAOYSA-N…
计算化学: 氢键受体数7.0氢键供体数2.0可旋转键数11.0

物理性质

沸点730.4±70.0 °C at 760 mmHg
闪点395.6±35.7 °C
密度1.3±0.1 g/cm3
pKa:14.96±0.10(预测)
PSA:129.14
LogP:4.11
折射率1.637
蒸汽压0.0±2.5 mmHg at 25°C
溶解性Soluble In DMSO
外观形态白色至类白色粉末
储存条件储存在 -20°C
产品应用该化合物用作对ED的第一线口服疗法,而不管病因如何. MIRODONAFILE在与抗血压剂或Α1阻塞器一起管理高血压,低尿道症状或良性先质高血清的病人时,也是安全,有效且良好的.

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P501-

合成工艺路线路线简述

2648610-92-6 = 862189-95-5
反应条件:1.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

= 862189-95-5
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C1.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C2.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C2.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C2.3 Solvents: Methanol; 2 H,65 °C2.4 Reagents: Sodium Ethoxide; 5 H,65 °C2.5 Solvents: Water; 2 H,65 °C2.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C3.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

103-76-4 + 18167-33-4 = 862189-95-5
反应条件:1.1 Reagents: Thionyl Chloride,Chlorosulfonic Acid Solvents: Dimethylformamide; 0 °C; 5 - 10 °C; 25 °C; 4 H,25 °C1.2 Reagents: Triethylamine Solvents: Ethyl Acetate; 0 °C; 0.5 H,0 °C2.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C2.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C3.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C3.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C3.3 Solvents: Methanol; 2 H,65 °C3.4 Reagents: Sodium Ethoxide; 5 H,65 °C3.5 Solvents: Water; 2 H,65 °C3.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C4.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

119-36-8 = 862189-95-5
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Sodium Iodide Solvents: Acetonitrile; 24 H,Reflux2.1 Reagents: Thionyl Chloride,Chlorosulfonic Acid Solvents: Dimethylformamide; 0 °C; 5 - 10 °C; 25 °C; 4 H,25 °C2.2 Reagents: Triethylamine Solvents: Ethyl Acetate; 0 °C; 0.5 H,0 °C3.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C3.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C4.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C4.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C4.3 Solvents: Methanol; 2 H,65 °C4.4 Reagents: Sodium Ethoxide; 5 H,65 °C4.5 Solvents: Water; 2 H,65 °C4.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C5.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C5.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

2648610-93-7 = 862189-95-5
反应条件:1.1 Reagents: Ammonia Solvents: Methanol; Rt -> 40 °C; 1 H,40 °C; 5 H,40 °C2.1 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 73.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C3.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C4.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C4.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C4.3 Solvents: Methanol; 2 H,65 °C4.4 Reagents: Sodium Ethoxide; 5 H,65 °C4.5 Solvents: Water; 2 H,65 °C4.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C5.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C5.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

56-40-6 = 862189-95-5
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Methanol; 0 °C; 0 °C -> 10 °C; 10 °C -> 65 °C; 3 H,65 °C2.1 Reagents: Triethylamine Solvents: Methanol; 1 H,Rt -> Reflux; Reflux -> 0 °C2.2 Reagents: Sodium Borohydride; 1 H,0 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,0 °C3.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 10 H,112 °C3.2 Reagents: Ammonia Solvents: Methanol; Rt -> 40 °C; 1 H,40 °C; 5 H,40 °C3.3 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C3.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 74.1 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C5.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C5.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C5.3 Solvents: Methanol; 2 H,65 °C5.4 Reagents: Sodium Ethoxide; 5 H,65 °C5.5 Solvents: Water; 2 H,65 °C5.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C6.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C6.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

= 862189-95-5
反应条件:1.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C1.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C1.3 Solvents: Methanol; 2 H,65 °C1.4 Reagents: Sodium Ethoxide; 5 H,65 °C1.5 Solvents: Water; 2 H,65 °C1.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C2.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

= 862189-95-5
反应条件:1.1 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C2.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C2.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C2.3 Solvents: Methanol; 2 H,65 °C2.4 Reagents: Sodium Ethoxide; 5 H,65 °C2.5 Solvents: Water; 2 H,65 °C2.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C3.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

= 862189-95-5
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C2.1 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C3.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C3.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C3.3 Solvents: Methanol; 2 H,65 °C3.4 Reagents: Sodium Ethoxide; 5 H,65 °C3.5 Solvents: Water; 2 H,65 °C3.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C4.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

2648610-94-8 = 862189-95-5
反应条件:1.1 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 72.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C2.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C3.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C3.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C3.3 Solvents: Methanol; 2 H,65 °C3.4 Reagents: Sodium Ethoxide; 5 H,65 °C3.5 Solvents: Water; 2 H,65 °C3.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C4.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

63744-92-3 + 53386-64-4 = 862189-95-5
反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 10 H,112 °C1.2 Reagents: Ammonia Solvents: Methanol; Rt -> 40 °C; 1 H,40 °C; 5 H,40 °C1.3 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 72.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C2.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C3.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C3.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C3.3 Solvents: Methanol; 2 H,65 °C3.4 Reagents: Sodium Ethoxide; 5 H,65 °C3.5 Solvents: Water; 2 H,65 °C3.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C4.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

5680-79-5 + 100-52-7 = 862189-95-5
反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 1 H,Rt -> Reflux; Reflux -> 0 °C1.2 Reagents: Sodium Borohydride; 1 H,0 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,0 °C2.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 10 H,112 °C2.2 Reagents: Ammonia Solvents: Methanol; Rt -> 40 °C; 1 H,40 °C; 5 H,40 °C2.3 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C2.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 73.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C3.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C4.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C4.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C4.3 Solvents: Methanol; 2 H,65 °C4.4 Reagents: Sodium Ethoxide; 5 H,65 °C4.5 Solvents: Water; 2 H,65 °C4.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C5.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C5.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39]

109-94-4 = 862189-95-5
反应条件:1.1 Reagents: Sodium Solvents: Ethanol; 24 H,35 °C1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; Ph 7,Cooled2.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 10 H,112 °C2.2 Reagents: Ammonia Solvents: Methanol; Rt -> 40 °C; 1 H,40 °C; 5 H,40 °C2.3 Reagents: Sodium Solvents: Ethanol; 6 H,78 °C2.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 73.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,20 °C3.2 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide; 14 H,25 °C4.1 Reagents: Acetic Anhydride Solvents: Ethyl Acetate; 25 °C; 1 H,25 °C4.2 Reagents: Ethyl Chloroformate Solvents: Tetrahydrofuran; 2 H,65 °C4.3 Solvents: Methanol; 2 H,65 °C4.4 Reagents: Sodium Ethoxide; 5 H,65 °C4.5 Solvents: Water; 2 H,65 °C4.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,65 °C5.1 Reagents: Sodium Solvents: Ethanol; 20 H,78 °C5.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
标题:Improved Synthesis Of Mirodenafil
作者:Sun,Zhao-Zhu; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2015 卷标:25(1) 页码:35-39

海关参考信息

2905121000-正丙醇
2921211000-乙二胺
2922110001-单乙醇胺
2922192100-二甲氨基乙醇
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2022244943-A1
优先权日:2021-05-21
标题 :Method for predicting recurrence of lung cancer, and pharmaceutical composition for recurrence inhibition
发明人：LEE HO-YOUNG
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present invention relates to: a method for providing information necessary in predicting the recurrence of lung cancer; a pharmaceutical composition for inhibiting the recurrence of lung cancer; and the like. Since the present inventors have identified that in slow-cycling cancer cells responsible for lung cancer recurrence, RGS2 is significantly increased and ATF4 is reduced, it is expected that by measuring the level of expression or activity of RGS2 and ATF4, the likelihood of lung cancer recurrence can be easily and quickly predicted. In addition, since the present inventors have identified that the growth of slow-cycling cancer cells can be inhibited and the apoptosis thereof can be induced by eliminating the expression of RGS2 or blocking the protein synthesis inhibitory action of RGS2, the present invention is expected to be also variously usable in the drug development of lung cancer recurrence inhibiting therapeutic agents for inhibiting the expression or activity of RGS2.

专利号:WO-2012172449-A1
优先权日:2011-06-13
标题:Lactams as beta secretase inhibitors
发明人：BRODNEY MICHAEL AARON
权利人:PFIZER; BRODNEY MICHAEL AARON
摘要:Compound and pharmaceutically acceptable salts of the compound are disclosed, wherein the compound has the structure (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. The compound of formula I is useful as beta secretase inhibitor for use in the treatment of Alzheimer's and other neurodegenerative and/or neurological disorders.

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主要参考文献

1: Cho MC, Paick JS. A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction. Ther Adv Urol. 2016 Apr;8(2):100-17. doi: 10.1177/1756287215625408. Epub 2016 Jan 19. Review.
2: Shim JS, Bae JH. Drug Concentration in Rat Plasma, Bladder, and Prostate After Mirodenafil Administration in a Chronic Pelvic Ischemia Model. Urology. 2016 May;91:244.e1-5. doi: 10.1016/j.urology.2016.02.017. Epub 2016 Feb 23. doi: 10.1517/14740338.2016.1131818. Epub 2016 Jan 9. Review. doi: 10.5213/inj.2015.19.1.19. Epub 2015 Mar 26.
5: Peak TC, Yafi FA, Sangkum P, Hellstrom WJ. Emerging drugs for the treatment of erectile dysfunction. Expert Opin Emerg Drugs. 2015 Jun;20(2):263-75. doi: 10.1517/14728214.2015.1021682. Epub 2015 Mar 5. Review. doi: 10.5534/wjmh.2014.32.3.145. Epub 2014 Dec 29.

合成参考文献

摘要:Leonardi R, Alemanni M. The management of erectile dysfunction: innovations and future perspectives. Arch Ital Urol Androl. 2011 Mar;83(1):60–2.
参考文献:10.1016/j.juro.2012.08.276
摘要:Gacci M. Editorial comment. J Urol. 2013 Mar;189(3):1013. doi: 10.1016/j.juro.2012.08.276.
参考文献:10.5534/wjmh.2014.32.1.18
摘要:Park HJ, Moon KH, Lee SW, Lee WK, Kam SC, Lee JH, Park NC. Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. World J Mens Health. 2014 Apr;32(1):18–27.