专利号:US-2008317700-A1 优先权日:2006-12-21 标 题:Synthesis and biological activity of photopolymerizable derivatives of glyphosate 发明人:NECKERS DOUGLAS C; BOGDANOVA ANETA; FEDOROV ANDREI V 权利人:UNIV BOWLING GREEN STATE 摘要:The present invention holds forth improvements in the field of herbicide synthesis, their application, and methods of plant and weed control and antifouling. The present invention includes the synthesis of new acrylate and methacrylate derivatives of a glyphosate. Two isomers resulting from a hindered rotation around the amide CN bond are observed for both acrylic and methacrylic analogs and barriers for internal rotation are obtained. Biological activity tests indicate that functionalized glyphosates possess herbicidal activity similar to the parent compound.
专利号:US-6217901-B1 优先权日:1999-05-25 标题:Liposome-assisted synthesis of polymeric nanoparticles 发明人:PERROTT MICHAEL G; BARRY STEPHEN E 权利人:ALNIS LLC 摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.
专利号:US-4980428-A 优先权日:1989-10-20 标 题 :Epoxy vinyl ethers and synthesis of an epoxy vinyl ether from a hydroxylated vinyl ether and a polyepoxide 发明人:LIU KOU-CHANG; VARA FULVIO J; DOUGHERTY JAMES A 权利人:GAF CHEMICALS CORP 摘要:This invention relates to epoxy vinyl ethers having the formula: ##STR1## wherein R is a polyvalent linear, branched or cyclic hydrocarbon radical having from 2 to 20 carbon atoms, optionally substituted with alkylenoxy; n has a value of from 1 to 20; p has a value of from 1 to 6; and at least one of Y and Y' is ##STR2## which any remaining Y and Y' can be ##STR3## The invention also relates to the synthesis and uses of the above polyphenyl vinyl ethers.
专利号:US-5831072-A 优先权日:1996-03-07 标 题:Process for the preparation of 2'-deoxy-2'-halocoformycins or steroisomers thereof 发明人:TAKEUCHI TOMIO; UMEZAWA SUMIO; TSUCHIYA TSUTOMU; TAKAHASHI YOSHIAKI 权利人:ZAIDAN HOJIN BISEIBUTSU 摘要:An object of this invention is to provide a novel process for the synthesis of a 2'-deoxy-2'-halocoformycin having an inhibitory activity against adenosine deaminase in a practically high yield. Thus, there is provided a process comprising multi-stage reactions with using as the starting intermediate a tert-butyl 1-(3,5-di-O-acyl-2-deoxy-2-halo-β-D-ribofuranosyl or arabinofuranosyl)-5-aminoimidazole-4-carboxylate of formula (II) ##STR1## whereby there are produced a 2'-deoxy-2'-halocoformycin or a 2'-deoxy-2'-epi-2'-halocoformycin of formula (I-a) ##STR2## and also a 2'-deoxy-8-epi-2'-halocoformycin or a 2'-deoxy-8,2'-diepi-2'-halocoformycin of formula (I-b) ##STR3## It is expectable that a 2'-deoxy-2'-halocoformycin and epimers thereof are useful as a drug for lymphocytic leukemias and as drugs for various diseases attributable to the actions of adenosine deaminase.
专利号:US-4980430-A 优先权日:1989-10-20 标题:Epoxy vinyl ethers and synthesis of an epoxy vinyl ether from a hydroxylated vinyl ether and a diepoxide 发明人:LIU KOU-CHANG; VARA FULVIO J; DOUGHERTY JAMES A 权利人:GAF CHEMICALS CORP 摘要:This invention relates to epoxy vinyl ethers having the formula: ##STR1## where R is a polyvalent linear, branched or cyclic hydrocarbon radical having from 2 to 20 carbon atoms, optionally substituted with alkyleneoxy; A is branched or linear C 1 to C 4 alkylene; B is halogen or lower alkyl; m has a value of from 0 to 4; n has a value of from 0 to 20; p has a value of from 1 to 5; and T is ##STR2## when p is one, and is ##STR3## or a mixture of ##STR4## and ##STR5## when p is greater than one.
专利号:US-9782748-B2 优先权日:2008-08-08 标题:Synthesis of polymeric ionic liquids using a photochemical polymerization process 发明人:ANDERSON JARED L 权利人:UNIV TOLEDO 摘要:Photo-initiated polymeric ionic liquids, methods of making and methods of using the same are disclosed. A preferred embodiment for making a photo-initiated polymeric ionic liquid (P-PIL) coated support, comprises: mixing at least one ionic liquid (IL) monomer with at least one photo-initiator; at least partially coating a support with the mixture; and exposing the coated support to UV light to form a photo-initiated polymeric ionic liquid (P-PIL) coated support.
[参考文献]: Takao Raku, Et Al. Chemoenzymatic Synthesis Of Optically Active, Biodegradable Polymers Based On Phenyl- And Naphthyl-Ethanols Esterified With Divinyladipate. Biotechnol Lett. 2004 Apr;26(8):665-70.
合成参考文献
摘要:Chen, P.; Liu, G.; Engle, K. M.; Yu, J.-Q., Science of Synthesis Knowledge Updates, (2013) 2, 72. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 314. 摘要:Vandamme, M.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2016) 1, 403. 摘要:Braun, M., Science of Synthesis Knowledge Updates, (2017) 1, 446. 摘要:Inamoto, K., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 414.