CAS: 1024-99-3; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-5-Iodopyrimidine-2,4(1H,3H)-Dione

相似化合物

58-96-8 26287-69-4 3083-77-0

上下游产品

2',3',5'-tri-O-acetyl-5-iodouridine ethanol uridine Tri-O-acetyluridine 3-Methyl-2',3'-O-dimethyl-O6,5'-cyclouridinN3-Methyl-2',3'-O-dimethyl-O6,5'-cyclouridin methyl 3-(5-uridinyl)propenoate uridine(E)-5-2-(ethoxycarbonyl)vinyluridine uridine

尿嘧啶核苷置于sodium Azide,一氯化碘体系中,用 乙腈 用作溶剂,化学反应 24.0H,以93%的收率获得5-碘尿苷
参考文献:一种通过 5-Halogeno-6-Azido-5,6-Dihydro 中间体合成 5-Halogeno 尿嘧啶核苷的温和有效的方法
标题:一种通过 5-Halogeno-6-Azido-5,6-Dihydro 中间体合成 5-Halogeno 尿嘧啶核苷的温和有效的方法
摘要:已开发出一种温和有效的方法来合成 5-卤代(碘,溴或氯)尿嘧啶核苷.5-Halo-2'-Deoxyuridines 4A-c (84-95%),5-Halo-Arabinouridines 7A-c (45-95%),And 5-Haloarabinouridines 8A-c (65-95%) 合成非常好2'-脱氧尿苷 (2),尿苷 (5) 和阿拉伯尿苷 (6) 分别与一氯化碘或 N-溴(或氯)琥珀酰亚胺和叠氮化钠在 25-45 oc 下反应生成.这些 C-5 卤化反应通过 5-卤代-6-叠氮基-5,6-二氢中间体 (3) 进行,从中消除 Hn3,反应生成5-卤代尿嘧啶核苷.5-Halo-6-Azido-5,6-Dihydro 中间产物 (10A,10B) 可以从 3',5'-Di-O-Acetyl-2'-Deoxyuridine (9) 与一氯化碘的反应中分离出来或 N-溴代琥珀酰亚胺和叠氮化钠在
Doi:10.1139/v94-256

专利信息

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2012178710-A1
优先权日:2009-07-01
标题 :Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof
发明人：JONES ROGER A; GAFFNEY BARBARA L
权利人:JONES ROGER A; GAFFNEY BARBARA L; UNIV RUTGERS
摘要:The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-2024384319-A1
优先权日:2021-09-17
标题 :Synthesis of Oligonucleotides
发明人：LOVELOCK SARAH
权利人:UNIV MANCHESTER
摘要:The present invention relates to a novel method for oligonucleotide synthesis, using a catalytic primer-template, e.g. a hairpin primer, to achieve multiple rounds of oligonucleotide synthesis and dissociation from the template in the same reaction, such that at the end of the reaction the amount of oligonucleotide generated is greater than the amount of template provided in the reaction. The primer contains a cleavable site and the reaction is carried out in a single mixture with a cleavage agent. The cleavable site may be an inosine and the agent an endonuclease V.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.