专利号:US-2015099864-A1 优先权日:2013-10-08 标题:Preparation of organophosphate peptide adducts 发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T 权利人:BATTELLE MEMORIAL INSTITUTE 摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.
专利号:US-6204398-B1 优先权日:1996-08-23 标题 :Preparation of cyclohexene carboxylate derivatives 发明人:KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN 权利人:GILEAD SCIENCES INC 摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
专利号:WO-2015053980-A1 优先权日:2013-10-08 标 题 :Preparation of organophosphate peptide adducts 发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T 权利人:BATTELLE MEMORIAL INSTITUTE 摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.
专利号:US-6608196-B2 优先权日:2001-05-03 标题 :Process for solid supported synthesis of pyruvate-derived compounds 发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L 权利人:GALILEO PHARMACEUTICALS INC 摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.
专利号:US-9522932-B2 优先权日:2004-03-04 标 题 :Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 发明人:HERDEWIJN PIET; PANNECOUQUE CHRISTOPHE; WU TONGFEI; DE CLERCQ ERIK 权利人:LEUVEN K U RES & DEV 摘要:The invention is directed to a process for the preparation of substituted threonolactone and substituted threose compounds which are intermediates in the synthesis of phosphonate nucleosides being useful antiviral agents.
专利号:US-2006106178-A1 优先权日:2002-08-06 标题:Synthesis of statistical microgels by means of controlled radical polymerisation