CAS: 2227-79-4; Benzothioamide

上下游产品

Thiobenzoic acid O-ethyl ester (Z)-benzaldoxime O-acetate benzamide benzaldehyde2-phenylthiazole benzonitrile N-xanthen-9-yl-thiobenzamideN-xanthen-9-yl-thiobenzamide 2-(4-methyl-2-phenylthiazol-5-yl)ethan-1-ol

氯化苄置于1,2,3,4,5,6,7,8-八硫杂环辛烷,Formamide,Sodium Hydroxide体系中,化学反应 8.0H,以79%的收率获得硫代苯甲酰胺
参考文献:无过渡金属,由氯代烃,酰胺和元素硫生成硫代酰胺的一般结构
标题:无过渡金属,由氯代烃,酰胺和元素硫生成硫代酰胺的一般结构
摘要:通过涉及氯代烃,酰胺和元素硫的三组分反应开发了一种无需过渡金属或外部氧化剂的一锅法合成硫代酰胺的通用方法.通过该协议,可以以中等至极好的收率获得烷基和芳基硫代酰胺.对氯代烃或酰胺上的各种取代基的高耐受性是合理的.值得注意的是,该协议不需要过渡金属或外部氧化剂.此外,还结合控制实验和量子化学计算对反应机制进行了研究.
Doi:10.1002/ejoc.202100588

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-3947517-A
优先权日:1969-06-12
标题:Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines
发明人：MUXFELDT HANS H; MICHAEL JEFFREY
权利人:RESEARCH CORP
摘要:In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.

专利号:EP-4423083-A2
优先权日:2021-11-29
标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
发明人：ÖNAY UÇAR EVREN; DEM RAYAK EREF; BERK BARKIN; YURTTA LEYLA; B LTEK N KALEL SEVDE NUR; AH N ZAFER
权利人:UNIV ISTANBUL MEDIPOL; ISTANBUL UNIV REKTORLUGU; ANADOLU UNIV
摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.

专利号:US-8552175-B2
优先权日:2009-04-23
标题:Sulfur transfer reagents for oligonucleotide synthesis
发明人：GUZAEV ANDREI P
权利人:GUZAEV ANDREI P; A M CHEMICALS INC
摘要:The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones, 5-phenyl-3H-1,2,4-dithiazole-3-thiones, and derivatives thereof as novel, efficient sulfur-transfer reagents is disclosed. Sulfur transfer from these reagents to compounds containing a P(III) atom (e.g., triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite), was studied in solution by 31 P NMR and HPLC. The sulfur transfer from title compounds was also studied in the solid-phase synthesis of oligonucleotide phosphorothioates by phosphoramidite methods. In this application, the efficiency of the sulfur transfer reaction for 2′-deoxyoligonucleotides was better than 99.5%. The novel sulfurizing agents are synthesized, at low cost, using simple chemical methods. As opposed to many sulfur transfer reagents known in the prior art such as 1,2-benzodithiol-3-one-1,1-dioxide (Beaucage reagent) and 5-ethoxy-3H-1,2,4-dithiazole-2-one (EDIT), the sulfurizing agents disclosed herein are highly stable in solution, which increases their practical and commercial value.

专利号:US-2023303546-A1
优先权日:2020-03-05
标题:Process And Intermediates For The Preparation Of Pyroxasulfone
发明人：RECSEI CARL; BARDA YANIV
权利人:ADAMA AGAN LTD
摘要:The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene bridge, to obtain a compound of Formula (I). The invention also relates to novel S-substituted thioisoxazole of Formula (III) and processes of preparation thereof, wherein L1 is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable thionating reagent: dimethyl thioformamide, thiosulfate salts, dithiooxamide, alkyl xanthate salts, thiobenzamide, V-substituted thiourea and thioacetate salts.

专利号:US-8927584-B2
优先权日:2011-02-22
标 题:Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof
发明人：WANG JEH-JENG; LIAO CHAO-CHENG; Hu wan-ping; SHEN HO-CHUAN
权利人:UNIV KAOHSIUNG MEDICAL
摘要:The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R 1 and R 2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.