CAS: 2362-64-3; 4-Methoxybenzothioamide

上下游产品

4-methoxybenzonitrile 4-methoxyphenylacetamide tetramethyldiamidothiophosphoric acid thioacetamide 2-(p-methoxyphenyl)-4-methylthiazole 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole 2-(4-methoxyphenyl)-1,3-thiazole p-tolyl-[2,4']bithiazolyl2'-(4-methoxy-phenyl)-4-p-tolyl-[2,4']bithiazolyl

5-P-Methoxyphenyl-1,2,4-Dithiazole-3-One置于l-半胱氨酸体系中,用 Aq. Phosphate Buffer,二甲基亚砜 用作溶剂,化学反应生成4-甲氧基硫代苯甲胺
参考文献: Compounds For Thiol-Triggered Cos And/or H2S Release And Methods Of Making And Using The Same[fr] Composés Pour La Libération De Cos Et/ou De H2S Déclenchée Par Thiol Et Leurs Procédés De Fabrication Et D'Utilisation
标题: Compounds For Thiol-Triggered Cos And/or H2S Release And Methods Of Making And Using The Same[fr] Composés Pour La Libération De Cos Et/ou De H2S Déclenchée Par Thiol Et Leurs Procédés De Fabrication Et D'Utilisation
摘要:本文揭示了一种化合物的实施例,该化合物能够在与含硫醇化合物反应时释放cos和/或h2S.该化合物实施例还可以在释放cos和/或h2S的同时产生可检测的信号(例如,荧光信号),和/或释放活性剂,如治疗剂.还公开了制备和使用该化合物实施例的方法.

专利信息

专利号:EP-4423083-A2
优先权日:2021-11-29
标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
发明人：ÖNAY UÇAR EVREN; DEM RAYAK EREF; BERK BARKIN; YURTTA LEYLA; B LTEK N KALEL SEVDE NUR; AH N ZAFER
权利人:UNIV ISTANBUL MEDIPOL; ISTANBUL UNIV REKTORLUGU; ANADOLU UNIV
摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.

专利号:US-8552175-B2
优先权日:2009-04-23
标题:Sulfur transfer reagents for oligonucleotide synthesis
发明人：GUZAEV ANDREI P
权利人:GUZAEV ANDREI P; A M CHEMICALS INC
摘要:The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones, 5-phenyl-3H-1,2,4-dithiazole-3-thiones, and derivatives thereof as novel, efficient sulfur-transfer reagents is disclosed. Sulfur transfer from these reagents to compounds containing a P(III) atom (e.g., triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite), was studied in solution by 31 P NMR and HPLC. The sulfur transfer from title compounds was also studied in the solid-phase synthesis of oligonucleotide phosphorothioates by phosphoramidite methods. In this application, the efficiency of the sulfur transfer reaction for 2′-deoxyoligonucleotides was better than 99.5%. The novel sulfurizing agents are synthesized, at low cost, using simple chemical methods. As opposed to many sulfur transfer reagents known in the prior art such as 1,2-benzodithiol-3-one-1,1-dioxide (Beaucage reagent) and 5-ethoxy-3H-1,2,4-dithiazole-2-one (EDIT), the sulfurizing agents disclosed herein are highly stable in solution, which increases their practical and commercial value.

专利号:US-2003199558-A1
优先权日:2001-12-28
标 题:Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners
发明人：DOOLEY THOMAS P; CHENG LIN
权利人:INTEGRIDERM INC
摘要:Methods, compounds, and formulations are provided to reduce pigmentation in mammalian skin, comprising hydroxamic acid and its derivatives, and especially benzohydroxamic acid and its derivatives. The compounds preferably inhibit pigment synthesis in melanocytes through inhibition of melanocyte tyrosinase. The methods can be used for lightening skin, and for treating uneven skin complexions, which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically, and preferably as topical formulations.

专利号:US-7858105-B2
优先权日:2000-02-29
标 题:Inhibitors of melanocyte tyrosinase as topical skin lighteners
发明人：DOOLEY THOMAS P; CURTO ERNEST V
权利人:MEDIQUEST THERAPEUTICS INC
摘要:Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenylthiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment synthesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

专利号:WO-2023096623-A2
优先权日:2021-11-29
标题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes

专利号:CN-108374182-B
优先权日:2018-02-27
标题 :A New Method for Electrochemical Synthesis of 1,2,4-Thiadiazole Compounds