CAS: 2555-28-4; 7-Methoxy-4-Methylcoumarin

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CAS号150-19-6 3-甲氧基苯酚 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号90-33-5 4-甲基伞形酮 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号4341-76-8 2-丁炔酸乙酯 | CAS号105-45-3 乙酰乙酸甲酯 | CAS号5394-63-8 2,2,6-三甲基-4H-1,... | CAS号4525-25-1 methyl (Z)-3-hy... | CAS号616-38-6 碳酸二甲酯 | CAS号529-84-0 4-甲基七叶亭 | CAS号4281-40-7 6,7-二甲氧基-4-甲基香豆素 | CAS号35231-44-8 4-溴甲基-7-甲氧基香豆素 | CAS号7706-67-4 地美罗酸 | CAS号10410-29-4 6-甲氧基-3-甲基苯并呋喃-2-甲酸 | CAS号33871-80-6 7-methoxy-2,2,4... | CAS号150-19-6 3-甲氧基苯酚 | CAS号71745-50-1 2-isopropyl-5-m... | CAS号72433-26-2 4-(羟甲基)-7-甲氧基-2... | CAS号75908-67-7 3-bromo-7-metho...

4-Methyl-7-Methoxy-2-Oxo-2H-1-Benzopyran-3-Carboxylic Acid置于铜体系中,化学反应 0.17H,反应生成7-甲氧基-4-甲基香豆素
参考文献:An Efficient Preparation Of Coumarins
标题:An Efficient Preparation Of Coumarins
摘要:O-Methoxyaryl-Aldehydes (Or-Ketones) React In Solid-Phase With Meldrum'S Acid Under Mild Conditions,To Give Benzylidene Derivatives Which Are Cyclized In High Yield,With Cold Sulfuric Acid To Substituted 3-Carboxycoumarins. Thermal Decarboxylation,Speed Up By Copper Powder,Provided An Easy Access To Numerous Coumarins.
Doi:10.1080/00397919308013801

专利信息

专利号:US-8309706-B2
优先权日:1998-08-03
标 题 :Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
发明人：DELLINGER DOUGLAS J; CARUTHERS MARVIN H; BETLEY JASON R
权利人:DELLINGER DOUGLAS J; CARUTHERS MARVIN H; BETLEY JASON R; AGILENT TECHNOLOGIES INC
摘要:The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect nucleophile irreversibly cleave the carbonate protecting groups while simultaneously oxidizing the internucleotide phosphite triester linkage to a phosphodiester linkage. The procedure may be carried out in aqueous solution at neutral to mildly basic pH. The method eliminates the need for separate deprotection and oxidation steps, and, since the use of acid to remove protecting groups is unnecessary, acid-induced depurination is avoided. Fluorescent or other readily detectable carbonate protecting groups can be used, enabling monitoring of individual reaction steps during oligonucleotide synthesis. The invention is particularly useful in the highly parallel, microscale synthesis of oligonucleotides.

专利号:US-7135565-B2
优先权日:2000-07-28
标题 :Synthesis of polynucleotides using combined oxidation/deprotection chemistry
发明人：DELLINGER DOUGLAS J; PERBOST MICHAEL G M; CARUTHERS MARVIN H; BETLEY JASON R
权利人:UNIV COLORADO
摘要:A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the second nucleoside having a hydroxyl protecting group that is a non-carbonate protecting group. The product of the foregoing step is exposed to a composition which both oxidizes the formed phosphite to a phosphate and deprotects the protected hydroxyl of the coupled nucleoside. The method has particular application to fabricating an addressable array of polynucleotides on a substrate which carries substrate bound moieties each with a hydroxyl group.

专利号:WO-2018152323-A1
优先权日:2017-02-17
标 题:Compositions and methods for template-free enzymatic nucleic acid synthesis
发明人：STEMPLE DEREK L; MANKOWSKA SYLWIA A; HARVEY STEVEN A
权利人:CAMENA BIOSCIENCE LTD; STEMPLE DEREK L
摘要:Disclosed are compositions and methods for template-free nucleic acid synthesis. Exemplary methods comprise deprotecting a primer comprising at least three nucleotides, wherein the primer comprises a 3' reversible terminating nucleotide (rtNTP), incorporating at least one free rtNTP by an enzyme or a ribozyme having a terminal transferase activity and repeating these steps until the desired synthetic nucleic acid is generated. Methods of the disclosure may be performed using primers in solution as well as primers linked to a substrate (e.g. including an array).

专利号:US-9889182-B2
优先权日:2009-09-15
标 题 :Assisted enzyme replacement therapy
发明人：ESKO JEFFREY D; TOR YITZHAK
权利人:ESKO JEFFREY D; TOR YITZHAK; UNIV CALIFORNIA
摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

专利号:US-6222030-B1
优先权日:1998-08-03
标题:Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection

专利号:EP-1553102-A1
优先权日:1998-08-03
标题:Synthesis of oligonucleotides