CAS: 33332-28-4; 2-Amino-6-Chloropyrazine

相似化合物

33332-29-5 59489-29-1 14399-37-2

上下游产品

2,6-dichloropyrazine 3-aminopyrazine 1-oxide 6-chloro-N-(4-methoxybenzyl)pyrazin-2-amine 4-Phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-ylamine 6-(4-Benzyl-piperidin-1-yl)-pyrazin-2-ylamine 3,5-dibromo-6-chloro-pyrazin-2-ylamine 2-chloro-3-bromo-6-aminopyrazine

2,6-二氯吡嗪置于ammonium Hydroxide体系中,化学反应 15.0H,以76%的收率获得2-氨基-6-氯吡嗪
参考文献:二氨基嗪衍生的偶氮化合物的颜色和组成
标题:二氨基嗪衍生的偶氮化合物的颜色和组成
摘要:可见吸收光谱已被记录为从2,5-Dichlorosulphanilic酸偶氮加上衍生的偶氮化合物,二乙基-间-苯二胺,并用吖嗪类似物.环氮杂取代基以及氰基对光谱的影响表明,两个环位置对偶氮基的敏感性都出乎意料的差异.Mo的计算表明,偶氮键邻位的氨基将不对称性引入homo,这是造成取代作用不同的原因.
Doi:10.1016/s0040-4020(01)91257-8

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-2021085684-A1
优先权日:2016-07-06
标 题:Pde9 inhibitors for treatment of peripheral diseases
发明人：SVENSTRUP NIELS; PARACHIKOVA ANNA I; MCARTHUR JAMES
权利人:IMARA INC
摘要:The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.

专利号:CN-117946013-B
优先权日:2024-01-25
标题:One-pot synthesis of 5,6-dihalogenated-3-aminopyrazine-2-carboxylic acid methyl ester

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:US-8937072-B2
优先权日:2011-06-17
标题:Substituted cyanoaniline compounds, preparation and use thereof
发明人：LIU CHANGLING; HUANG GUANG; LAN JIE; HAO SHULIN; LI ZHINIAN; LI HUICHAO; GUAN AIYING; JIANG AIRU; XU YING
权利人:LIU CHANGLING; HUANG GUANG; LAN JIE; HAO SHULIN; LI ZHINIAN; LI HUICHAO; GUAN AIYING; JIANG AIRU; XU YING; SINOCHEM CORP; SHENYANG RES INST CHEMICAL IND
摘要:Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively prevents against a variety of pathogens such as cucumber downy mildew, wheat powdery mildew, maize rust disease, rice blast and cucumber gray mold. In particular, even at a low dose, the compound effectively prevents and treats rice blast, cucumber gray mold, maize rust disease and cucumber downy mildew. Moreover, the raw materials for preparing the compounds are widely available and the synthesis method therefor is simple and convenient.

专利号:CN-112724089-B
优先权日:2021-01-05
标题 :A kind of synthesis technique of 2-amino-3-bromo-6-chloropyrazine