CAS: 453-20-3; 3-Hydroxytetrahydrofuran

相似化合物

86087-23-2 86087-24-3 86087-23-2

上下游产品

CAS号3068-00-6 1,2,4-丁三醇 | CAS号627-27-0 3-丁烯-1-醇 | CAS号38115-87-6 DL-苹果酸二甲酯 | CAS号19098-31-8 2-(oxiran-2-yl)... | CAS号1191-99-7 2,3-二氢呋喃 | CAS号68363-71-3 3-phenylmethoxy... | CAS号67-56-1 甲醇 | CAS号86852-11-1 Diethyloxytriph... | CAS号38300-67-3 1, 2, 4-三溴丁烷 | CAS号1708-29-8 2,5-二氢呋喃 | CAS号3068-00-6 1,2,4-丁三醇 | CAS号78-92-2 仲丁醇 | CAS号71-36-3 正丁醇 | CAS号27999-96-8 acetic acid,oxo... | CAS号86087-24-3 (R)-(-)-3-羟基四氢呋喃 | CAS号86087-23-2 (S)-(+)-3-羟基四氢呋喃 | CAS号2419-74-1 1,4-二氯-2-丁醇 | CAS号121138-01-0 3-碘代四氢呋喃 | CAS号13694-84-3 (S)-3-甲苯磺酰四氢呋喃 | CAS号22929-52-8 二氢-3(2H)-呋喃酮

Anhydroerythritol置于5-壬醇,甲基三氧化铼(Vii)体系中,用 十二烷,苯 作为反应溶剂,化学反应 45.0H,以10%的收率获得产物3-羟基四氢呋喃
参考文献:Oxorhenium-Catalyzed Deoxydehydration Of Glycols And Epoxides
标题:Oxorhenium-Catalyzed Deoxydehydration Of Glycols And Epoxides
摘要:The Conversion Of Renewable Cellulosic Biomass Into Hydrocarbons Has Attracted Significant Attention With A Growing Demand Of Sustainability. Mereo3 Catalyzes The Deoxydehydration (Dodh) Of Glycols And Epoxides To Alkenes By Primary And Secondary Alcohols (5-Nonanol,3-octanol,1-Butanol) In The Benzene Solvent. The Product Yield Range From Moderate To Excellent. (C) 2014 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2014.05.044

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-9233943-B2
优先权日:2012-01-10
标题:Process for synthesis of syn azido epdxide and its use as intermediate for the synthesis of amprenavir and saquinavir
发明人：GADAKH SUNITA KHANDERAO; REKULA REDDY SANTHOSH; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:A novel synthetic route to the syn-azido epoxide of formula 5 includes cobalt-catalyzed hydrolytic kinetic resolution of a racemic mixture of the azido-epoxide. Reaction steps include subjecting an allylic alcohol to epoxidation with mCPBA to obtain a racemic epoxy alcohol; ring opening the epoxy alcohol with azide anion to obtain an anti-azido alcohol, which can then be selectively tosylated at the primary alcohol; treating the tosylate with base to obtain the racemic azido-epoxide; and subjecting the racemic azido-epoxide to cobalt-catalyzed hydrolytic kinetic resolution to obtain the syn-azido epoxide of formula 5. The compound of formula 5 may be used as a common intermediate for the asymmetric synthesis of HIV protease inhibitors, such as Amprenavir, Fosamprenavir, Saquinavir, and formal synthesis of Darunavir and Palinavir.

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-6281367-B1
优先权日:1998-03-20
标 题:Process for the synthesis of HIV protease inhibitors
发明人：AL-FARHAN EMILE; DEININGER DAVID D; MCGHIE STEPHEN; O'CALLAGHAN JOHN; ROBERTSON MARK STUART; RODGERS KEITH; ROUT STEPHEN JOHN; SINGH HARDEW; TUNG ROGER DENNIS
权利人:GLAXO WELLCOME INC
摘要:An improved process for the synthesis of (3S)-tetrahydro-3-furyl N-[(1S,2R)-3 -(4-amino-N-isobutylbenzenesulphonamido)-1-benzyl-2-hydroxypropyl]carbamate comprising four steps form the compound of formula A and a novel intermediate thereto.

专利号:US-6087512-A
优先权日:1996-09-18
标题:Process for preparation of glycidyl ether
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; YANAGIMOTO TETSUYA; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of a glycidyl ether which is characrelized in reacting an epoxy compound of the formula ##STR1## wherein X is halogen or sulfonyloxy in the presence of a fluoride salt, with an alcohol. According to the above method, glycigyl ethers or their optically active compounds important as intermediates for synthesis of medicines are easily obtained in good yield and especially the optically active compounds are obtained with highly optical purity.

专利号:US-6057476-A
优先权日:1996-09-18
标题:Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of 3-amino-2-hydroxy-1-propyl ether of the formula ##STR1## wherein R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic ring, R 2 and R 3 are the same or different hydrogen atom, a substituted or unsubstituted alkyl, or may form a ring together with an adjacent nitrogen atom, which ring may be interrupted with nitrogen atom, oxygen atom or sulfur atom, n which is characterized in reacting an epoxy compound of the formula ##STR2## wherein X is halogen, in the presence of a fluoride salt, with an alcohol and then reacting an amine. n According to the above method, an intermediates for synthesis of medicines is obtained in good yield and highly optical purity.