CAS: 4693-02-1; 6-Nitro-1H-Benzo[d][1,3]Oxazine-2,4-Dione

上下游产品

isatoic anhydride 5-Bromo-1H-indole-2,3-dione chromium(lll) acetate 5-nitroisatin 1-(2-amino-5-nitro-benzoyl)-aziridine 1-(2-amino-5-nitro-benzoyl)-2,2-dimethyl-aziridine 2-amino-4-hydroxy-6-nitroquinazoline 6-Nitro-1-(3,4,5-trimethoxy-benzoyl)-1H-benzo[d][1,3]oxazine-2,4-dione

靛红酸酐置于硫酸,Potassium Nitrate体系中,化学反应 0.75H,以92%的收率获得产物5-硝基靛红酸酐
参考文献:两个6元稠合n杂环的便捷组装:通过cu介导的反应快速获得新颖的小分子.
标题:两个6元稠合n杂环的便捷组装:通过cu介导的反应快速获得新颖的小分子.
摘要:已经开发了一种快速,通用且一锅的cu介导的多米诺骨牌反应,可轻松组装两个六元稠合n杂环,从而产生新颖的小分子作为pde4的潜在抑制剂.
DOI:10.1039/c2Cc37070K

专利信息

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-2012189547-A1
优先权日:2009-10-08
标 题 :[18f] labelled analogues of flumazenil as in vivo imaging agents
发明人：WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
权利人:WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
摘要:The present invention provides radiofluorinated compounds useful for in vivo imaging GABA A receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.

专利号:US-6274383-B1
优先权日:1997-12-15
标题:Methods for synthesizing libraries of dihydro-quinazolinones
发明人：GAO YUN
权利人:SEPRACOR INC
摘要:Synthetic methods for solution and solid-phase synthesis of combinatorial libraries of dihydro-quinazolinones, including synthesis of 2,3-dihydro-3-alkoxy-4(1H)-quinazolinones or 2,3-dihydro-3-hydroxy-4(1H)-quinazolinones via the Lewis-acid catalyzed reaction of an appropriate 2-aminobenzamide with an aldehyde at ambient temperature performed on a solid support or in solution.

专利号:US-8946410-B2
优先权日:2009-10-08
标 题 :Automated radiosynthesis
发明人：WOODCRAFT JOHN; JONES L CLARE; GAETA ALESSANDRA; TRIGG JOHN WILLIAM; JONES ALEXANDER PAUL; PLANT STUART; JACKSON ALEXANDER
权利人:WOODCRAFT JOHN; JONES L CLARE; GAETA ALESSANDRA; TRIGG JOHN WILLIAM; JONES ALEXANDER PAUL; PLANT STUART; JACKSON ALEXANDER; GE HEALTHCARE LTD
摘要:The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABA A receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlabâ„¢. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.