CAS: 625471-18-3; (S)-Tert-Butyl 3-Aminopiperidine-1-Carboxylate

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N-Benzyl-(S)-Proline Methyl Ester置于lithium Aluminium Tetrahydride,Sodium Azide,10% Palladium On Activated Charcoal,氢气,碳酸氢钠,三氟乙酸酐体系中,用 四氢呋喃,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,-78.0~90.0 °C,101.33 Kpa 条件下,反应 153.66H,反应生成 (S)-1-Boc-3-氨基哌啶
参考文献:The Synthesis Of Piperidine Nucleoside Analogs-a Comparison Of Several Methods To Access The Introduction Of Nucleobases
标题:The Synthesis Of Piperidine Nucleoside Analogs-a Comparison Of Several Methods To Access The Introduction Of Nucleobases
摘要:This Work Deals With The Synthesis Of Piperidine And Hydroxypiperidine Analogs Of Nucleosides. Starting From Commercially Available 3-Hydroxypiperidine,Proline Or 4-Hydroxyproline,A Series Of Piperidine Derivatives Of Both Purine And Pyrimidine Nucleobases Was Prepared. Various Methods Of Nucleobase Attachment Were Evaluated. The Prepared Compounds Were Tested For Cytostatic,Antibacterial,And Antiviral Properties But No Significant Activity Was Found. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2010.12.029

专利信息

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-9487539-B2
优先权日:2009-09-18
标 题 :Compounds and therapeutic use thereof for protein kinase inhibition
发明人：WU ZHANGGUI
权利人:WU ZHANGGUI
摘要:Novel compound having the following formula: n nwherein Y is N, O, or S. Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.

专利号:CN-114249680-B
优先权日:2022-01-10
标 题:A kind of indole derivative and its synthesis method and application

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.

专利号:CN-111647634-A
优先权日:2020-07-09
标题:A kind of method of packed bed continuous flow asymmetric synthesis (S)-1-Boc-3-aminopiperidine

专利号:CN-118255777-A
优先权日:2024-04-09
标 题 :Synthesis and application of a class of CDK7 inhibitors