CAS: 939-48-0; Isopropyl Benzoate

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CAS号108-20-3 异丙醚 | CAS号98-88-4 苯甲酰氯 | CAS号35118-50-4 邻苯二甲酸单异丙酯 | CAS号67-63-0 异丙醇 | CAS号65-85-0 苯甲酸 | CAS号155164-66-2 2-benzoyl-4,5-d... | CAS号2902-69-4 2,2,2-三氯苯乙酮 | CAS号100-52-7 苯甲醛 | CAS号591-50-4 碘苯 | CAS号201230-82-2 carbon monoxide | CAS号459-57-4 对氟苯甲醛 | CAS号100-52-7 苯甲醛 | CAS号4044-60-4 2,5-二甲基苯甲酮 | CAS号7338-94-5 1,3-二苯基丙-2-炔-1-酮 | CAS号120-51-4 苯甲酸苄酯 | CAS号67-64-1 丙酮 | CAS号617-94-7 2-苯基-2-丙醇 | CAS号120-46-7 二苯甲酰甲烷 | CAS号67-63-0 异丙醇 | CAS号65-85-0 苯甲酸

异丙基苄基醚置于potassium Carbonate,1-(过氧化叔丁基)-1,2-苯碘酰-3(H)-酮体系中,用 苯 作为反应溶剂,化学反应 36.0H,以71%的收率获得产物苯甲酸异丙酯
参考文献:高价(叔丁基过氧)碘在室温下在溶液中反应生成以碘为中心的自由基:苄基和烯丙基醚的氧化和脱保护,以及反应生成 α-氧碳自由基的证据
标题:高价(叔丁基过氧)碘在室温下在溶液中反应生成以碘为中心的自由基:苄基和烯丙基醚的氧化和脱保护,以及反应生成 α-氧碳自由基的证据
摘要:1-(Tert-Butylperoxy)-1,2-Benziodoxol-3(1H)-One (1A) 在室温下,在苯或环己烷中,在碱金属碳酸盐存在下,将苄基和烯丙基醚氧化成酯.由于该反应与其他保护基团(例如 Mom,Thp 和 Tbdms 醚以及乙酰氧基)相容,并且由于酯在碱性条件下容易水解,因此这种新方法为通常的还原性脱保护提供了一种方便有效的替代方法.与 1A 的氧化很容易发生,C-H 键被焓效应(苄基,烯丙基和炔丙基 C-H 键)和/或极性效应(α-氧 C-H 键)激活,反应生成 α-氧碳中心自由基,可以通过硝酰基自由基捕获来检测.
DOI:10.1021/ja9610287

专利信息

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:WO-2008032104-A1
优先权日:2006-09-15
标题:One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：WALKER ROSS THOMSON; NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD; WALKER ROSS THOMSON; NAIDU RAGINA
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction, of protecting the C-10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

专利号:US-7202370-B2
优先权日:2003-10-27
标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
发明人：NAIDU RAGINA
权利人:CONOR MEDSYSTEMS INC
摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.

专利号:US-2005192445-A1
优先权日:2004-03-01
标题:Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:PHYTOGEN LIFE SCIENCES INC
摘要:A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannne and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.

专利号:US-9040444-B2
优先权日:2009-12-22
标 题:Semi continuous process for the synthesis of a catalyst for use in the manufacture of polyolefins
发明人：SINGALA KAMLESH; SINGH SAURABH; GUPTA VIRENDRAKUMAR
权利人:SINGALA KAMLESH; SINGH SAURABH; GUPTA VIRENDRAKUMAR; RELIANCE IND LTD
摘要:A semi-continuous process and system thereof, for the synthesis of a narrow particle size distribution Zeigler Natta procatalyst for use in the manufacture of polyolefins. The process comprises: (a) mixing a reaction mixture containing a titanium compound; (b) charging a first reactor with said reaction mixture; (c) removing excess reactants from said first reactor as a filtrate; (d) feeding said filtrate to at least one further reactor; and continuously removing excess reactants from said at least further reactor.