CAS: 114715-39-8; (R)-1-Benzylpyrrolidin-3-Amine

相似化合物

18471-40-4 103831-11-4 114715-38-7

上下游产品

1-苄基-3-氨基吡咯烷 1-Benzyl-3-Aminopyrrolidine 18471-40-4
(3R)-3-Azido-1-(Phenylmethyl)Pyrrolidine 116143-03-4
(3S)-3-Azido-1-(Phenylmethyl)Pyrrolidine 114636-29-2
(S)-3-羟基-1-苄基吡咯烷 (S)-N-Benzyl-3-Hydroxypyrrolidine 101385-90-4
(R)-(+)-N-苄基-3-羟基吡咯烷 (R)-N-Benzyl-3-Hydroxypyrrolidine 101930-07-8
(3R)-(+)-1-苄基-3-(叔丁氧羰基氨基)吡咯烷 (3R)-1-Benzyl-3-[(Tert-Butoxycarbonyl)(Methyl)Amino]Pyrrolidine 131878-23-4

(S)-3-羟基-1-苄基吡咯烷 反应生成(R)-1-苄基-3-氨基吡咯烷
参考文献:抗菌剂7-(3-氨基吡咯烷-1-基)-1-(2,4-二氟苯基)-1,4-二氢-6-氟-4-氧代-1,8的对映异构体的不对称合成及其性质-萘啶-3-羧酸盐酸盐.
标题:抗菌剂7-(3-氨基吡咯烷-1-基)-1-(2,4-二氟苯基)-1,4-二氢-6-氟-4-氧代-1,8的对映异构体的不对称合成及其性质-萘啶-3-羧酸盐酸盐.
摘要:化合物1 [7-(3-氨基吡咯烷-1-基)-1-(2,4-二氟苯基)-1,4-二氢-6-氟咯-4-羰基-1,8-萘啶-3-羧酸盐酸]是喹诺酮羧酸类抗菌剂的有效成员,目前正在临床评估中.我们已经开发了该试剂的对映异构体的有效不对称合成.在体外,S-(+)对映异构体1A的抗氧性比r-(-)对映异构体1B的活性高1-2个log2稀释,对厌氧菌具有1-2个或更多log2稀释.对映异构体1A在铜绿假单胞菌小鼠保护模型中显示出比消旋体1更好的体内活性.再加上1A相对于消旋体材料的溶解度改善,从临床角度来看,这些特征可能具有实际意义.
Doi:10.1021/jm00403A017

专利信息

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.