CAS: 122839-52-5; (R)-2-Amino-3-(4-Fluorophenyl)Propanoic Acid Hydrochloride

相似化合物

18125-46-7 64231-54-5 169243-86-1

上下游产品

(R)-4-fluoro-N-benzoyl-phenylalanine trans-cinnamic acidα-benzoylamino-4-fluoro-trans-cinnamic acid(R)-2-Amino-3-(4-fluorophenyl)-1-propanol

α-Benzoylamino-4-Fluoro-Trans-Cinnamic Acid置于盐酸,Cationic Rhodium Complex With (-)-(R)-"Propraphos",氢气体系中,用 甲醇 用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 4.0H,反应生成对氟-D-苯丙氨酸盐酸盐
参考文献:Unusual Amino Acids
标题:Unusual Amino Acids
摘要:Few (Z)-Alpha-N-Benzoylamino-Beta-(Fluorophenyl)-Acrylic Acids And Their Esters Were Prepared By Known Procedures And Hydrogenated To The Corresponding Optically Active Alpha-Benzoyl-Beta-(Fluorophenyl)-Alanine Derivatives With Optical Yields Up To 90% Using The Rhodium Complexes Of "Propraphos" And O,N-Bis(Diphenylphosphino)-2-Exo-Hydroxy,3-Endo-Methylamino-Norbornane As Chiral Catalysts. The Method Proved To Be Apt For Upscaling The Preparation. Deacylation Of The Obtained Amino Acids Gave The Hydrochlorides Of The Fluorinated Phenylalanines In Very Pure State.
Doi:10.1016/s0957-4166(00)80262-1