CAS: 1532-97-4; 4-Bromoisoquinoline

相似化合物

223671-10-1 34784-04-8 81045-39-8

上下游产品

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异喹啉置于n-溴代丁二酰亚胺(Nbs)体系中,用 溶剂黄146 用作溶剂,化学反应生成4-溴异喹啉
参考文献:Bromination Of Isoquinoline,Quinoline,Quinazoline And Quinoxaline In Strong Acid
标题:Bromination Of Isoquinoline,Quinoline,Quinazoline And Quinoxaline In Strong Acid
摘要:苯并吡嗪和苯并二嗪的溴化反应通常得到多种产物混合物.本文中,我们展示了异喹啉(1)可在浓硫酸中使用nbs或在三氟甲磺酸中使用n,N'-二溴异氰尿酸(dbi)进行区域选择性单溴化,得到5-溴异喹啉(2).研究发现,溴化反应对溴化剂,酸,温度和浓度的选择非常敏感.喹啉,喹唑啉和喹喔啉亦可进行类似溴化,尽管其区域选择性不如异喹啉强烈.
Doi:10.1055/s-2002-19314

专利信息

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

专利号:US-2009234126-A1
优先权日:2006-03-21
标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide

专利号:JP-2009530403-A
优先权日:2006-03-21
标 题 :Synthesis of arylamines from reactions of aromatic compounds with ammonia or metal amides.

专利号:CA-2646978-A1
优先权日:2006-03-21
标 题:Process for the synthesis of arylamines from the reaction of an aromaticcompounds with ammonia or a metal amide

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.