CAS: 1606-85-5; 2,2-(But-2-Yne-1,4-Diylbis(Oxy))Diethanol

相似化合物

3973-18-0 208827-90-1 1036204-61-1

2,2'-(But-2-Yne-1,4-Diylbis(Oxy))Diethanol Ditrityl Ether置于对甲苯磺酸体系中,用 四氢呋喃,甲醇 用作溶剂,以73%的收率获得丁炔二醇乙氧基化物
参考文献:通过低聚乙二醇的高环化高效合成单分散聚乙二醇及其衍生物
标题:通过低聚乙二醇的高环化高效合成单分散聚乙二醇及其衍生物
摘要:已开发出一种基于大环硫酸盐(mcs)的单分散聚乙二醇(m-Peg)及其单官能化衍生物的方法.寡聚乙二醇(oeg)的大环化提供了mcs(最多62个成员的大环),作为一系列单官能化m-Peg的通用前体.通过mcs的反复亲核开环反应而无需进行基团保护和激活,可以轻松制备一系列m-Peg,包括史无前例的64-Mer(2850 Da).合成简单性与这种新策略的多功能性可能为m-Peg的更广泛应用铺平道路.
Doi:10.1002/anie.201410309

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.