CAS: 2439-10-3; Dodine

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CAS号124-22-1 十二胺 | CAS号420-04-2 氰胺 | CAS号64-19-7 冰醋酸

溶剂黄146,十二烷基胍单盐酸盐置于sodium Hydroxide体系中,用 甲苯 用作溶剂,化学反应 1.0H,以95%的收率获得多果定
参考文献:一种多果定的合成方法
标题:一种多果定的合成方法
摘要:本发明提供了一种多果定的合成方法,该方法以盐酸胍为起始原料,将其与氯代十二烷反应制得中间体a,接着向中间体a中加入强碱水溶液进行反应,然后加入冰醋酸反应,后处理,制得目标产物多果定.该合成方法原料易得,反应步骤少,反应条件温和,操作简单,收率较高,并且是一种环境友好型的合成方法,因此,适用于大规模工业化生产,具有很好的应用前景与市场潜力.

专利信息

专利号:US-2023391631-A1
优先权日:2022-05-23
标题:Metal cations as inorganic structure directing agents during the synthesis of phillipsite and tobermorite
发明人：SIMONETTI DANTE; Vega-Vila Juan Carlos; SANT GAURAV; HOLKAR ADVAIT; SRIVASTAVA SAMANVAYA; ARNOLD ROSS
权利人:UNIV CALIFORNIA
摘要:The present disclosure relates to zeolites comprising Al, Si, O, H, Na, K and Ca, wherein the zeolite advantageously comprises phillipsite and tobermorite phases. The present disclosure further provides methods of preparing the zeolites from a synthesis gel.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:WO-2020020904-A1
优先权日:2018-07-23
标题:Therapeutic uses of glp-2 agonists
发明人：LINDSTRÖM ERIK; SKARBALIENE JOLANTA
权利人:ZEALAND PHARMA AS
摘要:The invention relates to the use of GLP-2 agonists to modulate bile acid metabolism. In particular, it is believed that GLP-2 agonists may be capable of inhibiting bile acid synthesis, and so are useful for the treatment of conditions in which inhibition of bile acid synthesis is beneficial. Such conditions include primary bile acid diarrhea, secondary bile acid diarrhea and conditions which cause or contribute to cholestasis. The invention further relates to the use of FGF19 and C4 as biomarkers to monitor bile acid synthesis and homoeostasis, e.g. in SBS patients.

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人：FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.