CAS: 514797-99-0; 3-Chloro-5-Fluoropyridine

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851179-00-5 372-47-4 626-60-8

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CAS号514797-97-8 2-溴-5-氯-3-氟吡啶 | CAS号248255-70-1 5-氯-3-氟-2-肼基吡啶 | CAS号89402-43-7 2,3-二氟-5-氯吡啶 | CAS号514797-96-7 2-羟基-3-氟-5-氯吡啶 | CAS号514798-05-1 2-溴-5-氯-3-氟-4-碘吡啶 | CAS号372-47-4 3-氟吡啶 | CAS号2200-71-7 4,4'-二甲氧基八氟联苯 | CAS号2546-56-7 4-氯-3-氟吡啶 | CAS号851178-98-8 3-氯-4,5-二氟吡啶 | CAS号851179-02-7 3,4-二氯-5-氟吡啶

2-溴-3-氟-5-氯吡啶置于sodium Hydroxide,锌体系中,化学反应 6.0H,以92%的收率获得产物3-氟-5-氯吡啶
参考文献:Creating Structural Manifolds From A Common Precursor: Basicity Gradient-Driven Isomerization Of Halopyridines
标题:Creating Structural Manifolds From A Common Precursor: Basicity Gradient-Driven Isomerization Of Halopyridines
摘要:5-Chloro-2,3-Difluoropyridine,An Intermediate In The Manufacturing Process Of An Industrial Pesticide,Can Be Hydrolyzed To 5-Chloro-3-Fluoro-2H-Pyridinone And The Latter Converted Into 2,5-Dichloro-3-Fluoropyridine (1A),2-Bromo-5Chloro-3-Fluoropyridine (1B),5-Chloro-3-Fluoro-2-Iodopyridine (1C) And 3-Chloro-5-Fluoropyridine (1D). Consecutive Treatment Of These Four Substrates With Lithium Diisopropylamide And Carbon Dioxide Or Lithium Diisopropylamide And Iodine Affords The Corresponding 4-Pyridinecarboxylic Acids 2 And 4-Iodopyridines 3,Respectively. Amide-Promoted Deprotonation Of Such 4-Iodopyridines 3 Triggers An Isomerization In Which Lithium And Iodine Change Places. The Resulting Species Can Be Trapped With Carbon Dioxide To Give The Acids 5A-C Or Neutralized To Give The Halopyridines 4A-C. The Iodopyridines 4A And 4B Can Be Converted Into The Acids 6A And 6B,The Latter Product Leading Also To The Congeners 6C And 6D. The Diiodopyridine 4C Provides An Entry To The Halopyridine 4D,Which At The Same Time May Act As The Precursor To The Acid 5D,The Acid 7 Or The Bisacid 8. Finally,The Acid 9 Is Accessible From Either One Of The 5-Chloro-3-Fluoro-2-Halopyridines 1B And 1C. (C) Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2002).
DOI:10.1002/1099-0690(200212)2002:24<4174::Aid-Ejoc4174>3.0.Co;2-6