CAS: 54-64-8; Thimerosal

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:WO-2021250635-A1
优先权日:2020-06-11
标题:Acid salts of fluoroquinolone carboxylic acid based compositions and methods of making and using the same
发明人：GHOSH SUMANA; BHATTACHARYYA ANAMIKA; SINGH HIMANSHI; SADHASIVAM SURESH; SINHA MAU; GARG MUKESH KUMAR; GARKHAL KALPNA; KUMAR MUKESH; KHARE PRAGATI; GUPTA SWATI; SENGUPTA SHILADITYA; CHAVDARIAN CHARLES G
权利人:VYOME THERAPEUTICS INC
摘要:The present disclosure is in the field of pharmaceutical and chemical sciences. The present disclosure generally relates to the synthesis of therapeutic agents, processes for preparing said agents, compositions comprising said therapeutic agents and their uses. In particular, the disclosure relates to medicinally important acid salts of fluoroquinolone carboxylic acid based chemical molecules [compounds of formula (I)], method of preparing said molecules, compositions thereof, and the use of such molecules as therapeutic agents. The said acid salts of fluoroquinolone carboxylic acid based chemical molecules are useful in treating infections such as ear infections, otitis, otitis media including acute otitis media, recurrent otitis media, otitis media with effusion, chronic otitis media, chronic suppurative otitis media, otitis externa (including acute otitis externa, chronic otitis externa), otitis interna and combinations thereof.

专利号:US-2008095693-A1
优先权日:2004-07-09
标题 :Methods and Apparatus for Production and Use of [11C] Carbon Monoxide in Labeling Synthesis
发明人：KIHLBERG TOR; LANGSTROM BENGT; FERM TOMMY; ERIKSON JONAS
权利人:KIHLBERG TOR; LANGSTROM BENGT; FERM TOMMY; ERIKSON JONAS
摘要:Methods and apparatus for production and use of carbon-isotope monoxide in labeling synthesis are provided. The resultant carbon-isotope labeled reagents are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided

专利号:US-2003138490-A1
优先权日:2001-09-08
标 题 :Synthesis and uses of polymer gel nanoparticle networks
发明人：HU ZHIBING; LU XIHUA; GAO JUN; PONDER BILL C; JOHN JOHN ST; MORO DANIEL G
摘要:Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.

专利号:US-2006159608-A1
优先权日:2004-12-03
标题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation

专利号:US-2006171882-A1
优先权日:2005-02-01
标 题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled compounds by thermally induced free radical carbonylation