CAS: 619-72-7; 4-Nitrobenzonitrile

上下游产品

CAS号555-16-8 对硝基苯甲醛 | CAS号17271-88-4 1-(azidomethyl)... | CAS号7291-01-2 Benzamide, N,N-... | CAS号7409-30-5 4-硝基苄胺 | CAS号52898-51-8 N-甲氧基-N-甲基-4-硝基苯甲酰胺 | CAS号6388-74-5 2-(4-硝基苯基)环氧乙烷 | CAS号99-77-4 对硝基苯甲酸乙酯 | CAS号619-73-8 对硝基苯甲醇 | CAS号1129-37-9 4-硝基苯甲醛肟 | CAS号873-74-5 对氨基苯腈 | CAS号35704-19-9 4'-氰基乙酰基苯胺 | CAS号122045-07-2 4,4'-(diazene-1... | CAS号4714-67-4 4-氨基硫代苯甲酰胺 | CAS号57611-19-5 5-(氯甲基)-3-(4-硝基... | CAS号13520-07-5 4-morpholinoiso... | CAS号34133-58-9 2,4-二氰基苯酚 | CAS号134165-33-6 5-cyano-1-(2,4-... | CAS号636-46-4 4-羟基间苯二甲酸 | CAS号19619-22-8 4-氨基间苯二腈

4-硝基苯乙烯置于甲酸,Sodium Nitrite体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以84%的收率获得产物对硝基苯甲腈
参考文献:以亚硝酸盐为氮源和氧化剂的c C双键断裂直接合成腈
标题:以亚硝酸盐为氮源和氧化剂的c C双键断裂直接合成腈
摘要:使用容易获得的nano 2作为氮源和氧化剂,已经开发出烯烃的c C键向腈的转化.可以成功制备高收率的几种具有各种取代基的芳基杂环腈.基于实验观察,提出了可能的反应机理.
DOI:10.1016/j.Tetlet.2016.04.108

专利信息

专利号:US-2009221834-A1
优先权日:2006-04-20
标题 :Synthesis of 5-Beta-Keto-1,2,4-Oxadiazoles and Conversion of 5-Beta-Keto-1,2,4 Oxadiazoles to N-Pyrazolyl Amidoximes
发明人：JENSEN DAVID R; SIDENSTICK JOHN E
权利人:JENSEN DAVID R; SIDENSTICK JOHN E
摘要:The disclosed invention relates to a process for preparing 5-β-keto-1,2,4-oxadiazoles of formula (I), and conversion of 5-β-keto-1,2,4-oxadiazoles (I) into N-pyrazolyl amidoximes of the formula (II) through reaction with hydrazine. The process is defined by two steps. An amidoxime, which may be prepared in situ, is condensed with a β-keto ester to form a 5-β-keto-1,2,4-oxadiazole. The 5-β-keto-1,2,4-oxadiazole is subsequently reacted with hydrazine to furnish the desired N-pyrazolyl amidoxime. The disclosed invention provides several advantages over the current state of the art for the synthesis of N-pyrazolyl amidoximes, which require the condensation of a pyrzolylamine with an actived substrate and subsequent reaction with hydroxyl amine. N-pyrazolyl amidoximes are useful synthetic intermediates, especially for the preparation of photographic developing chemicals.

专利号:US-7074921-B2
优先权日:2001-11-13
标题 :Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds
发明人：KRONENTHAL DAVID R; BHANDARU RAO S; SHI ZHONGPING; MUDRYK BOGUSLAW M
权利人:BRISTOL MYERS SQUIBB CO
摘要:Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.

专利号:CN-113861119-A
优先权日:2021-11-23
标题:A kind of method for cobalt-catalyzed synthesis of quinoline and quinazoline compounds

专利号:US-7569606-B2
优先权日:2006-01-26
标 题 :Platinum complexes with mononitrile-containing ligands
发明人：XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

专利号:EP-2013190-A2
优先权日:2006-04-20
标题 :SYNTHESIS OF 5-ß-KETO-1,2,4-OXADIAZOLES AND CONVERSION OF 5-ß-KETO-1,2,4-OXADIAZOLES TO N-PYRAZOLYL AMIDOXIMES