CAS: 6298-03-9; H-Lys(Aloc)-Oh

相似化合物

147529-99-5 146982-27-6 214750-75-1

上下游产品

α-(tert-butoxycarbonyl)-Nε-(allyloxycarbonyl)-L-lysineNα-(tert-butoxycarbonyl)-Nε-(allyloxycarbonyl)-L-lysine L-lysine Allyl chloroformate CitrullineB°C-Phe-Lys (all°C)-OH N-Cbz-Phe-Lys(ε-All°C)OH Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Nα-(Tert-Butoxycarbonyl)-Nε-(Allyloxycarbonyl)-L-Lysine 以 二氯甲烷,三氟乙酸 作为反应溶剂,化学反应 3.0H,反应生成 (S)-6-(((烯丙氧基)羰基)氨基)-2-氨基己酸
参考文献:钯催化氢化三丁基锡的反应.氨基酸的烯丙基和烯丙氧基羰基衍生物的选择性非常温和的脱保护.
标题:钯催化氢化三丁基锡的反应.氨基酸的烯丙基和烯丙氧基羰基衍生物的选择性非常温和的脱保护.
摘要:烯丙基(all)和烯丙氧基羰基(alloc)氨基酸衍生物通过bu 3 Snh以高选择性的方式通过钯催化的氢化锡烷基水解进行脱保护.苄基和苄氧羰基在这些条件下是稳定的.此外,烯丙基和alloc基团似乎与叔丁基和叔丁氧羰基保护基团正交.
DOI:10.1016/s0040-4039(00)84530-X

专利信息

专利号:WO-2024261319-A1
优先权日:2023-06-23
标题 :Methods of chemical synthesis of peptides
发明人：AL MUSAIMI OTHMAN; WILLIAMS DARYL ROBERT
权利人:IMPERIAL COLLEGE INNOVATIONS LTD
摘要:The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-2016304571-A1
优先权日:2010-03-24
标 题 :Synthesis of Site Specifically-Linked Ubiquitin

专利号:EP-4041249-A1
优先权日:2019-10-10
标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-2013065272-A1
优先权日:2010-03-24
标题 :Synthesis of Site Specifically-Linked Ubiquitin