CAS: 896464-16-7; Tert-Butyl 2,7-Diazaspiro[3.5]Nonane-7-Carboxylate

相似化合物

1023301-84-9 236406-55-6 929302-18-1

上下游产品

CAS号1206969-92-7 2-苄基-2,7-二氮杂螺[3... | CAS号1194374-44-1 2-苄基-2,7-二氮杂螺[3.5]壬烷

Tert-Butyl 4-(Chloromethyl)-4-Cyanopiperidine-1-Carboxylate置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,以76 %的收率获得产物2,7-二氮杂螺[3.5]壬烷-7-甲酸叔丁酯
参考文献:Cn116514811
标题:Cn116514811

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-2012010186-A1
优先权日:2009-03-23
标题:Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; TRANMER GEOFFREY K; MARTINS EVELYN; GAREAU YVES
权利人:LACHANCE NICOLAS; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; TRANMER GEOFFREY K; MARTINS EVELYN; GAREAU YVES; MERCK FROSST CANADA LTD
摘要:Heterocyclic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer, liver steatosis; and non-alcoholic steatohepatitis.

专利号:WO-2025088073-A1
优先权日:2023-10-24
标 题:Heterocyclic compounds as blt2 agonists and their medical use
发明人：HERNANDEZ-OLMOS VICTOR; HEERING JAN; PROSCHAK EUGEN; STEINHILBER DIETER; WEIGERT ANDREAS
权利人:FRAUNHOFER GES FORSCHUNG; JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN
摘要:[1] Herein, novel compounds of formula (III) that act as selective agonists of the leukotriene B4 receptor 2 (BLT2) receptor are presented. The invention pertains to these compounds, their synthesis, as well as their medical use, amongst others in the treatment of pain and inflammatory skin diseases such as psoriasis.