CAS: 1451-82-7; 2-Bromo-4'-Methylpropiophenone

上下游产品

4'-methylpropiophenone α-bromopropionyl bromide toluene bromine 2-hydroxy-1-(4-methylphenyl)propan-1-one 2-iodo-1-(p-tolyl)propan-1-one 1-(4-methylphenyl)-2-methylaminopropan-1-one p-tolyl-propan-1-one2-(5-amino-2-imino-[1,3,4]thiadiazol-3-yl)-1-p-tolyl-propan-1-one

3-(Dimethylamino)-2-Methyl-1-(P-Tolyl)Prop-2-En-1-One置于氢溴酸体系中,用 乙腈 用作溶剂,化学反应 3.0H,以53%的收率获得2-溴-4'-甲基苯丙酮
参考文献:Access To α,α-Dihaloacetophenones Through Anodic C C Bond Cleavage In Enaminones
标题:Access To α,α-Dihaloacetophenones Through Anodic C C Bond Cleavage In Enaminones
摘要:
Doi:10.1016/j.Tetlet.2021.153575

专利信息

专利号:US-6600016-B1
优先权日:1999-08-24
标题:Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
发明人：CAMPIAN EUGENE; LU BOLIANG; ZHANG JINFANG
权利人:ADVANCED SYNTECH LLC
摘要:Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at least two more attachment points which carry mutiple functionalized benzyl-type linkers. Each linker displays differing chemical stability under cleavage conditions so that products can be selectively and sequentially cleaved and separated from the reaction vessel. The linkers are independently different benzyl-type moieties, and each product synthesized on the linkers may have a different chemical structure. The support resin may further comprise an additional linker which is directly attached to the resin backbone. This linker can benzyl-type linkers or other traditional cleavable-linkers. The invention is further directed to a method for the production of mutiple combinatorial libraries in a simultaneous fashion utilizing the above described support resin. The products are selectively cleaved under conditions where only one linker site is cleaved so that the product is individually separated from the reaction vessel.

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

专利号:US-6583318-B2
优先权日:2001-05-17
标 题:Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives
发明人：CAMPIAN EUGENE; LOU BOLIANG; MJALLI ADNAN M M
权利人:ADVANCED SYNTECH LLC
摘要:A method of synthesizing alpha-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three reactants to form an array of polymer-bound alpha-sulfonamido amide-type intermediates and use of such intermediates for the preparation of combinatorial libraries.

专利号:US-2003013910-A1
优先权日:2001-05-17
标 题:Method for synthesis of alpha-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives

专利号:US-6268504-B1
优先权日:1997-10-15
标题 :Aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN R; REN JIANXIN; IERA SILVIO
权利人:AMERICAN HOME PROD
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, -NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SO2-Ar, -CO-R1, -CO-Ar, -CO2-R1, or -CO2-Ar; and Y is selected from a) the moiety:wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-2014121238-A1
优先权日:2011-03-29
标 题:Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents