CAS: 17159-80-7; Ethyl 4-Hydroxycyclohexanecarboxylate

相似化合物

3618-04-0 75877-66-6 869193-57-7

上下游产品

Ethyl 4-hydroxybenzoate ethyl 4-ox°Cyclohexane-1-carboxylate ethanol 4-hydroxycyclohexanecarboxylic acid4-chloro-1-cyclohexanecarboxylic acid chloride 1-Phenylsulfon-2-oxo-2-(4-hydroxy-cyclohexyl)ethan ethyl 4-ox°Cyclohexane-1-carboxylate 4-hydroxycyclohexane-1-carboxamide

过氧化氢酶置于rh/al2O3 氢气体系中,用 乙醇 用作溶剂,20.0 °C,506.62 Kpa 条件下,反应 20.0H,以100%的收率获得4-羟基环己烷甲酸乙酯
参考文献:Potentiating Effects Of .Beta.-Eudesmol-Related Cyclohexylidene Derivatives On Succinylcholine-Induced Neuromuscular Block In Isolated Phrenic Nerve-Diaphragm Muscles Of Normal And Alloxan-Diabetic Mice.
标题:Potentiating Effects Of .Beta.-Eudesmol-Related Cyclohexylidene Derivatives On Succinylcholine-Induced Neuromuscular Block In Isolated Phrenic Nerve-Diaphragm Muscles Of Normal And Alloxan-Diabetic Mice.
摘要:白术中含有的倍半萜醇β-Eudesmol能增强琥珀胆碱(such)诱导的神经肌肉阻滞作用.与正常肌肉相比,糖尿病肌肉的增效作用更大.作为研究其增效机制的亲和层析配体,我们设计并合成了新的β-桉叶油醇相关环己亚基衍生物(2-(3-羟基-3-甲基丁基)环己亚基.Kte-13,2-(3-羟基-3-甲基丁基)环己亚基.Kte-13,2-(3-羟基-3-甲基丁基)环己亚基.Kte-13);Kte-13,2-(3-羟基-3-甲基丁基)-4-环己亚基羧酸;Kte-32 和 4-叔丁氧羰基-2-(3-羟基-3-甲基丁基)环己亚基;Kte-33).我们研究了这些化合物在正常小鼠和阿脲糖尿病小鼠膈神经-膈肌制备物中的增效作用.与正常肌肉相比,Kte-33(100 μm)对糖尿病肌肉中苏合香诱导的神经肌肉阻滞的增效作用更大(正常肌肉和糖尿病肌肉中的增效比分别为 6.7 和 10.6),而 Kte-13 (100 μm)和-32 (200 μm)的增效作用较弱.这些结果表明,Kte-33 中的酯基而不是 Kte-32 中的羧基是诱导糖尿病状态下 Such 诱导的神经肌肉阻滞增效的重要因素.
Doi:10.1248/bpb.18.407

专利信息

专利号:US-5648484-A
优先权日:1995-03-07
标 题 :Catalytic enantioselective synthesis of a spriofused azetidinone
发明人：WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:A process for producing a compound of the formula ##STR1## comprises the following sequence of steps: ##STR2## wherein the various radicals are as defined in the specification.

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:WO-9627587-A1
优先权日:1995-03-07
标题 :Catalic enantioselective synthesis of a spiro-fused azetidinone

专利号:US-3535367-A
优先权日:1966-04-21
标题:Process for synthesis of 4-hydroxycyclohexanecarboxylic acid and derivatives thereof
发明人：INOUE GORO; KATO TOSHIO; PREFECTURE SAITAMA; OHSHIMA NOBORU
权利人:ASAHI CHEMICAL IND

专利号:CN-100402475-C
优先权日:2006-05-16
标题:Method for direct chlorination synthesis of chlorohydrocarbon adopting chlorosilane carbonyl compound