CAS: 201003-48-7; N-Fmoc-N'-Boc-N'-Isopropyl-L-Lysine

相似化合物

1313054-37-3 111061-54-2 1272755-60-8

上下游产品

Fm°C-Lys(tert-butoxycarbonyl) 24H30N2O4C24H30N2O4 tert-butyl dicarbonatedi-tert-butyl dicarbonate Fm°C-Lys-OH

Fmoc-赖氨酸置于sodium Carbonate,三氟乙酸体系中,用 甲醇,叔丁醇 用作溶剂,化学反应 2.0H,反应生成N-Fmoc-N'-Boc-N'-异丙基-L-赖氨酸
参考文献:Novel Cxcr4 Antagonists With Amino Acid Skeleton,Preparation Therefor And Biomedical Use Thereof
标题:Novel Cxcr4 Antagonists With Amino Acid Skeleton,Preparation Therefor And Biomedical Use Thereof
摘要:本发明提供一种由式(I)表示的化合物,或其药用可接受的盐或前药.

专利信息

专利号:US-12098218-B2
优先权日:2015-12-17
标题 :Process for the manufacture of degarelix and its intermediates
发明人：RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

专利号:CN-103351428-A
优先权日:2013-08-05
标 题 :Synthesis of degarelix by a solid-phase fragmentation method

专利号:CN-112876541-B
优先权日:2019-11-29
标题:A kind of solid-phase synthesis method of degarelix

专利号:CN-103351428-B
优先权日:2013-08-05
标题:A kind of solid phase fragment method synthesis Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2