CAS: 2358-29-4; 2,3,6-Trifluorobenzoic Acid

该化合物是一种芳烃式的碳酸,其特征是,在2,3和6个位置上,苯环上附着三个氟原子,与碳酸组相对,这种化合物因其高酸性,因为氟化物替代品的电脱色作用,稳定了脱氧时形成的碳酸箱状离子;它一般是白色晶状固体,在水和酒精等极溶剂中可溶解;氟原子的存在可增强它的再活性,并可在各种化学反应中影响其相互作用,使其在有机合成中有用,并作为生产药品和农用化学品的中间体;此外,2,36-三氟苯乙酸可以显示出独特的特性,例如,与非氟化对应体相比,脂性增加,并改变沸点和熔点;在处理这种化合物时,应采取安全防范措施,因为如果吸入吸入或吸入,可能会对健康造成危害.

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CAS号124-38-9 二氧化碳 | CAS号367-23-7 1,2,4-三氟苯 | CAS号136514-17-5 2,3,6-三氟苯甲腈 | CAS号2367-82-0 1,2,3,5-四氟苯 | CAS号32890-92-9 2,3,4,6-四氟苯甲酸 | CAS号1868-85-5 (α,α,α,2,3,5,6-... | CAS号327-52-6 2,4,5-三氟溴苯 | CAS号455-38-9 间氟苯甲酸 | CAS号65-85-0 苯甲酸 | CAS号2991-28-8 2,5-二氟苯甲酸 | CAS号367-23-7 1,2,4-三氟苯 | CAS号114152-19-1 2,3,6-三氟苯甲醇

合成工艺路线路线简述

    2,3,6-三氟苯腈置于硫酸体系中,化学反应生成2,3,6-三氟苯甲酸
    参考文献:2,3-Difluoro-6-Nitrobenzonitrile And
    标题:2,3-Difluoro-6-Nitrobenzonitrile And
    摘要:本发明描述了新型中间体2,3-二氟-6-硝基苯腈和2-氯-5,6-二氟苯腈,以及它们的制备方法和它们在制备2,3,6-三氟苯甲酸方面的优势用途,而2,3,6-三氟苯甲酸则是制备杀虫剂和抗菌剂的有价值的中间体.根据本发明,所述中间体是通过氟/氰交换和随后的脱硝氯化从2,3,4-三氟硝基苯制备而成.2,3,6-三氟苯甲酸可以通过文献已知的简单氯/氟交换和随后的水解制备而成,这个过程整体上在工业上具有优势和经济上有利.

    海关参考信息

    专利信息


    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:WO-2024126692-A1
    优先权日:2022-12-15
    标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes
    发明人:SCHOLZ HENRIK; KROKE EDWIN; KRAUSHAAR KONSTANTIN; GLATZER HOLGER JÜRGEN; LEWIS KENRICK MARTIN; WAGNER ROLAND
    权利人:MOMENTIVE PERFORMANCE MAT GMBH
    摘要:The present invention is directed at a process for producing a compound of Formula (I): (R1)y(R2O)3-ySiCH2CHR3CR4R5X comprising reacting (a) an olefinic halide; (b) an alkoxysilane; (c) a catalytically effective amount of iridium-containing catalyst; and (d) a reaction-promoting effective amount of a peroxycarboxylic acid to produce the product of Formula (I).

    专利号:EP-4634196-A1
    优先权日:2022-12-15
    标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:EP-0539274-B1
    优先权日:1991-10-24
    标题 :Method for the synthesis of aldehydes and of their derivatives

    专利号:JP-3615811-B2
    优先权日:1991-10-24
    标 题 :Catalysts for the synthesis of aldehydes and their derivatives
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    主要参考文献

    [参考文献]: V Mukherjee, Et Al. Ftir And Raman Spectra And Optimized Geometry Of 2,3,6-Tri-Fluorobenzoic Acid Dimer: A Dft And Sqmff Study. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Nov;77(4):787-94.

    合成参考文献


    摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 125.
    摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 144.
    摘要:Nelson, D. J., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 2, 281.
    摘要:Franck, X.; Durandetti, M., Science of Synthesis: Knowledge Updates, (2024) 3, 317.
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