CAS: 2389-60-8; Z-Lys(Boc)-Oh

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L-赖氨酸置于碳酸氢钠,Copper(II) Sulfate体系中,用 四氢呋喃,水 用作溶剂,化学反应生成Nε-Boc-Nα-Cbz-L-赖氨酸
参考文献:由α-氨基酸合成对映体纯的1,2-乙二胺与分子式为h2Nch2Ch [(ch2)n Nhme] Nh2(n = 1-4)的束缚仲胺:不对称催化的新剂
标题:由α-氨基酸合成对映体纯的1,2-乙二胺与分子式为h2Nch2Ch [(ch2)n Nhme] Nh2(n = 1-4)的束缚仲胺:不对称催化的新剂
摘要:作为特别主题的一部分发表,酰胺键形成的最新进展 抽象 三(盐酸盐)的标题化合物的加合物是从廉价的制备α-氨基酸ħ 2 N(c = O)ch 2 Ch(nh 2)co 2 H,Ho(c = O)(ch 2)ñ " Ch (nh 2)co 2 H(n '= 1,2)和h 2 N(ch 2)4 Ch(nh 2)co 2 H(步数/总收率= 5/32%,7/30%,7/33%,5/38%).通过bh 3还原酰胺[-(c = O)nr 2来安装远离仲胺的nh 2基团 由α-氨基羧酸衍生的].通过bh 3还原氨基甲酸烷基酯[ro(c = O)nhch 2-来引入menhch 2单元.R = Et,T-Bu]或酰胺[mehn(c = O)-]部分.
Doi:10.1055/s-0040-1707146

专利信息

专利号:WO-2010103857-A1
优先权日:2009-03-12
标 题 :Method for solid-phase synthesis of glycopeptide using silicon-containing protecting group and synthesis device
发明人：NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
权利人:UNIV HOKKAIDO NAT UNIV CORP; NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
摘要:Disclosed are a novel method for the synthesis of a glycopeptide by which glycopeptides of various types can be deprotected and excised from a resin, each under weakly acidic to weakly basic conditions, without causing the problems of the epimerization of an amino acid at the a-position and the ß-elimination of a sugar residue; a synthesis device therefor; and a synthesis intermediate to be used in synthesizing a glycopeptide. Specifically disclosed are a method for the solid-phase synthesis of a glycopeptide which comprises a step for obtaining a glycopeptide derivative wherein the N-terminus is protected, the C-terminus is immobilized to a solid phase via a silicon linker, and a reactive group carried by a sugar residue and a reactive group carried by an amino acid side chain constituting a peptide are protected by silicon-containing groups, and a step for obtaining the glycopeptide by deprotecting said glycopeptide derivative and releasing the same from the solid phase by treating the glycopeptide derivative with an agent for removing the silicon-containing groups and the silicon linker; a synthesis intermediate to be used in the step for obtaining the glycopeptide derivative in the aforesaid method; and a device for the solid-phase synthesis of a glycopeptide.

专利号:US-12018094-B2
优先权日:2018-04-02
标 题 :Crystalline dipeptides useful in the synthesis of elamipretide
发明人：DUNCAN SCOTT M; REDMON MARTIN P
权利人:STEALTH BIOTHERAPEUTICS INC
摘要:Disclosed are crystalline forms of L-Lys(Boc)-Phe-NH2 and Boc-D-Arg-DMT. The crystalline forms may be used in the synthesis of elamipretide.

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:US-8350042-B2
优先权日:2008-01-31
标题 :Antiviral compounds for the treatment of HCV infection
发明人：HERMANN THOMAS C; CARNEVALI MAIA
权利人:UNIV CALIFORNIA; HERMANN THOMAS C; CARNEVALI MAIA
摘要:Disclosed are compounds and methods of synthesis of Formula I for the development of antiviral drugs for the treatment of HCV infection.

专利号:US-10112976-B2
优先权日:2014-06-30
标 题:Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
发明人：ZHAO XINJUN; ZHENG MINYU; YU XIAOZHONG; GAO HANRONG; CORNILLE FABRICE
权利人:FLAMMA SPA
摘要:The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.