CAS: 4432-31-9; 2-Morpholinoethanesulfonic Acid

相似化合物

145224-94-8 39946-25-3 71119-23-8

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CAS号3240-94-6 4-(2-氯乙基)吗啉 | CAS号110-91-8 吗啉 | CAS号32797-12-9 sulfoacetaldehyde

2-Morpholin-4-Yl-Ethanesulfonic Acid 4-(Tert-Butyldiphenylsilanyloxy)-2,2-Dimethylbutyl Ester置于四丁基氟化铵体系中,用 四氢呋喃 作为反应溶剂,化学反应 48.0H,以72%的收率获得产物2-吗啉乙磺酸
参考文献:A New Strategy For The Synthesis Of Taurine Derivatives Using The 'safety-Catch' Principle For The Protection Of Sulfonic Acids
标题:A New Strategy For The Synthesis Of Taurine Derivatives Using The 'safety-Catch' Principle For The Protection Of Sulfonic Acids
摘要:安全捕获原理被用于开发一种保护磺酸的新方法.将 2,2-二甲基丁二酸还原为 2,2-二甲基丁烷-1,4-二醇,然后将其选择性地硅烷化,得到 4-(叔丁基二苯基硅氧基)-2,2-二甲基丁烷-1-醇.在三乙胺存在下,将后一种化合物与 2-氯乙烷磺酰氯反应,可直接得到 4-(叔丁基二苯基硅氧基)-2,2-二甲基丁基乙烯磺酸盐.乙烯磺酸盐与仲胺发生迈克尔式加成反应,得到牛磺酸的受保护衍生物(2-氨基乙磺酸).在用四丁基氟化铵处理时,硅氧键裂解产生中间烷氧基,立即循环到 2,2-二甲基四氢呋喃中,并释放出磺酸盐,从而实现脱保护.通过在强碱性树脂上进行离子交换色谱,并用乙酸水溶液洗脱,从粗产物中获得了纯磺酸.所开发的方法应普遍适用于磺酸的保护,并可用于多平行格式.
DOI:10.1039/b614333D

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:WO-2009033269-A1
优先权日:2007-09-11
标 题 :Novel polysaccharide immunogens from alloiococcus otitidis and synthesis of a glycoconjugate vaccine thereof
发明人：MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
权利人:UNIV GUELPH; MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
摘要:The application relates to Alloiococcus otitidis cell surface polysaccharides, compositions comprising Alloiococcus otitidis cell surface polysaccharides, synthesis of a glycoconjugate vaccine and includes kits, methods and uses thereof.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-8420848-B2
优先权日:2009-01-09
标题:Process for the synthesis of beta glycerol phosphate
发明人：KULKARNI YASHWANT
权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC
摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.