CAS: 5231-96-9; 2-Acetamidopyridine

上下游产品

CAS号504-29-0 2-氨基吡啶 | CAS号108-24-7 乙酸酐 | CAS号75-36-5 乙酰氯 | CAS号105-53-3 丙二酸二乙酯 | CAS号6994-14-5 N-(1-氧化吡啶-2-基)乙酰胺 | CAS号7169-97-3 2-乙酰氨基-5-溴吡啶 | CAS号109-09-1 2-氯吡啶 | CAS号60-35-5 乙酰胺 | CAS号107264-09-5 1-氟吡啶四氟硼酸盐 | CAS号75-05-8 乙腈 | CAS号504-29-0 2-氨基吡啶 | CAS号86847-59-8 2-特戊酰胺基吡啶 | CAS号882029-13-2 3-(2-三甲基乙酰氨基-3-... | CAS号29096-60-4 3-乙酰基-2-甲基咪唑[1,... | CAS号16075-67-5 pyrido[1,2-a]py... | CAS号14150-95-9 2-氨基吡啶 N-氧化物 | CAS号2446-62-0 8,9-二氢-6H-吡啶并[2... | CAS号6994-14-5 N-(1-氧化吡啶-2-基)乙酰胺 | CAS号57097-28-6 pyridin-2-amine... | CAS号61122-83-6 (2-methylimidaz...

2-乙炔基吡啶置于sodium Azide,C16H17Aubrn3O,水,三氟乙酸体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 2.0H,以72%的收率获得产物2-乙酰氨基吡啶
参考文献:由含吡啶基官能化nhc配体的au(i)配合物催化的炔烃酰胺水合合成
标题:由含吡啶基官能化nhc配体的au(i)配合物催化的炔烃酰胺水合合成
摘要:合成了在配体骨架上带有吡啶基的au(i)-Nhc络合物[l 1 Aubr](1),并评估了其在酸性水中由炔烃和叠氮化钠直接合成酰胺的催化效果.催化剂1在tfa / Dce(2 Ml,1:1 V / V)中催化剂负载量低的情况下,很容易将各种内部和末端炔烃转化为相应的酰胺)在室温下以较短的反应时间(2 H)进行,并且不使用ag(i)添加剂.不含吡啶基片段的相关催化剂显示出明显较低的活性,说明了启动子配体对水活化的作用.机理研究表明,炔烃最初会水合成酮,然后进行schmidt反应反应生成酰胺.
DOI:10.1016/j.Jorganchem.2019.02.011

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:WO-2024013736-A1
优先权日:2022-07-12
标题 :Process for preparing substituted benzamides
发明人：HAMIRANI BHAVINKUMAR; MAHESH GANDHAM; SREEDEVI MANNAM; PILLAI BIJUKUMAR GOPINATHAN
权利人:ADAMA MAKHTESHIM LTD
摘要:The present invention relates to new intermediates for the preparation of pyridylmethylbenzamides via substituted hydroxyiminopyridines or acetamidopyridines, and their innovative preparation processes. The invention discloses, in particular, the total synthesis of fluopicolide fungicide. The preparation of the main substances of the fluopicolide synthesis, specifically, substituted pyridine-2-ylmethanamine or its salt, is disclosed via two different synthesis routes, comprises two novel substances.

专利号:US-2015133663-A1
优先权日:2011-09-22
标题:Novel synthesis method
发明人：ACHANATH RADHA; JOSE JINTO; RANGASWAMY CHITRALEKHA; MANDAL SUBRATA; KADIVILPPARAMPU MOHAMED AFSAL MOHAMMED; NEWINGTON IAN MARTIN; BALAJI SRINATH
权利人:GE HEALTHCARE LTD
摘要:The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT 1A . The method of the present invention provides advantages over the known methods of synthesis. The compounds obtained by the method of the invention have use in therapeutic methods. The compounds of the invention may also optionally compose a moiety suitable for detection by an in vivo imaging procedure and as such these compounds have use in in vivo imaging methods. The compounds have particular use in the treatment and diagnosis of various neurological and/or psychiatric disorders.

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2657717-A1
优先权日:2006-07-15
标 题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-B
优先权日:2006-07-15
标 题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles