CAS: 58069-82-2; Urea-13C

该化合物是一个碳原子被碳-13同位素取代的稳定的同位素标签的尿素化合物,其中碳原子之一被碳-13同位素所取代.Urea本身是一种无色晶体物质,在水中高度溶解,主要以其在氮循环中的作用和哺乳动物中的氮废物产品而闻名.碳-13同位素的结合允许其用于各种科学应用,特别是核磁共振光谱和代谢研究,在这种研究中,跟踪生物系统中碳的移动和转化至关重要.Urea-13C是无毒的,并经常用于研究追踪代谢途径,评估蛋白合成和研究氮代谢,其特性包括C2H4N2O的分子分子公式,相对较低的分子重量和中性pH溶液.作为标签的化合物,它为生物化学过程提供了有价值的见解,而不会显著改变所涉分子的行为.

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上下游产品

CAS号35803-45-3 尿苷-2-13C | CAS号201996-37-4 氰尿酸-13C3

合成工艺路线路线简述

    Potassium <13C>Cyanate置于硫酸氢铵,Ammonium Hydroxide体系中,化学反应 4.0H,以87%的收率获得产物尿素-13C
    参考文献:Concomitant Oxygen‐18 Enrichment In Commercial Carbon‐13 Labelled Urea
    标题:Concomitant Oxygen‐18 Enrichment In Commercial Carbon‐13 Labelled Urea
    摘要:By Mass Spectroscopy,50-Fold Oxygen-18 Enrichment Over Natural Abundance Was Observed In Commercial C-13-Urea (99 Atom % C-13) Synthesized From C-13-Carbon Monoxide That Had Been C-13-Enriched By Cryogenic Distillation. In Contrast,C-13-Urea Synthesized From C-13-Potassium Cyanide (A C-13-Labelled Compound Having No Oxygen Atom) Showed The Natural Abundance Level Of Oxygen-18.
    DOI:10.1002/(Sici)1099-1344(199612)38:12<1133::Aid-Jlcr935>3.0.Co;2-#

    海关参考信息

    专利信息


    专利号:US-2023158470-A1
    优先权日:2022-07-26
    标题:Continuous synthesis system of urea
    发明人:QING JING; YOU HENGZHI; CHEN KAI; HAN QUANSHENG; LI GUOWEI; Liao Jingyuan; JIA XUELEI; DAI DESHENG
    权利人:SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD; HARBIN INST TECHNOLOGY SHENZHEN
    摘要:A continuous synthesis system of urea, including: a reactor, a mixing buffer tank for accommodating a first raw material, a feeding pump for pumping the first raw material to the reactor, a pressure regulating valve connected to the reactor to transfer a second raw material and regulate a pressure of the second raw material, a first heat exchanger connected to the reactor to regulate a temperature inside the reactor to a first preset temperature, and a back pressure valve connected to an end of the reactor away from the feeding pump to maintain a pressure of the continuous synthesis system at a preset pressure. The second raw material is gaseous. The second raw material is fed to the reactor through the pressure regulating valve to react with the first raw material in the reactor to generate a target product.

    专利号:US-12357601-B2
    优先权日:2017-03-17
    标题 :Composition for inhibiting growth of bacterium having menaquinone synthesis pathway through futalosine or futalosine derivative
    发明人:MATSUI HIDENORI; KAWAGUCHI MARINA
    权利人:NOSTER INC
    摘要:The present invention provides a composition for inhibiting proliferation of a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative, which contains a fatty acid having 18 carbon atoms and a hydroxyl group at the 10-position as an active ingredient. Furthermore, the present invention provides a composition for preventing or treating a disease caused by a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative.

    专利号:US-2023124002-A1
    优先权日:2022-07-26
    标 题 :Continuous-flow synthesis method of 13c-urea

    专利号:EP-4324809-A1
    优先权日:2022-07-26
    标题:Continuous-flow synthesis method of 13c-urea

    专利号:EP-4324809-B1
    优先权日:2022-07-26
    标 题:Continuous-flow synthesis method of 13c-urea
    发明人:QING JING; YOU HENGZHI; CHEN KAI; HAN QUANSHENG; LI GUOWEI; Liao Jingyuan; JIA XUELEI; DAI DESHENG
    权利人:SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD; HARBIN INST TECHNOLOGY SHENZHEN

    专利号:ES-2955046-T3
    优先权日:2017-03-17
    标题 :Composition for inhibiting the growth of a bacteria that has a menaquinone synthesis pathway through futalosin or a futalosin derivative
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    合成参考文献

    合成方法参考DOI号:10.1002/(SICI)1099-1344(199612)38:12<1133::AID-JLCR935>3.0.CO;2-#
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