CAS: 626-86-8; 6-Ethoxy-6-Oxohexanoic Acid

相似化合物

141-28-6 627-91-8 629-11-8

上下游产品

CAS号14660-52-7 5-溴戊酸乙酯 | CAS号124-38-9 二氧化碳 | CAS号5299-60-5 6-羟基己酸乙酯 | CAS号1190-69-8 6-氨基-6-酮基己酸乙酯 | CAS号611-10-9 环戊酮-2-羧酸乙酯 | CAS号4450-39-9 ethyl 5-cyanope... | CAS号542-69-8 碘代正丁烷 | CAS号78437-79-3 ethyl (6-(2-met... | CAS号124-04-9 己二酸 | CAS号141-78-6 乙酸乙酯 | CAS号1071-71-2 6-氯-6-氧代己酸乙酯(硫辛酸杂质) | CAS号4144-62-1 5-苯甲酰基戊酸 | CAS号56721-43-8 6-OXO-6-(2-THIE... | CAS号42916-80-3 ethyl 6-(4-meth... | CAS号5963-14-4 8-甲基壬酸 | CAS号4248-25-3 ethyl 6-oxo-6-p... | CAS号1862-10-8 N,N',N'-trimeth... | CAS号1968-40-7 4-戊炔甲酸乙酯 | CAS号143-07-7 月桂酸 | CAS号611-10-9 环戊酮-2-羧酸乙酯

己二酸二乙酯置于silica Gel体系中,用 丙酮 作为反应溶剂,化学反应 0.5H,以35%的收率获得产物己二酸单乙酯
参考文献:二羧酸酯的二氧化硅介导的单水解
标题:二羧酸酯的二氧化硅介导的单水解
摘要:为了战胜统计分布,选择在硅胶表面二羧酸酯的单选择性硅烷醇解作为水解的初始步骤.因此,开发了一种非常实用和选择性的羧酸半酯,适用于刚性芳族二酯以及柔性脂肪族二酯.
DOI:10.1002/ejoc.202101443

专利信息

专利号:US-6441246-B1
优先权日:1998-08-27
标题:Catalytic synthesis of aldehydes by direct hydrogenation of carboxylic acids
发明人：YAMAMOTO AKIO; NAGAYAMA KAZUHIRO
权利人:JAPAN SCIENCE & TECH CORP
摘要:A process which makes it possible to prepare aldehydes under mild reaction conditions with a high efficiency through the reduction of carboxylic acids with molecular hydrogen. Specifically, a process of reducing an organic carboxylic acid with molecular hydrogen in the presence of a catalyst into an aldehyde corresponding to the acid, characterized by conducting the reduction in the presence of a dehydrating agent such as a carboxylic anhydride.

专利号:US-8344168-B2
优先权日:2006-06-14
标题 :Process for the preparation of fluticasone propionate
发明人：GORE VINAYAK G; GADAKAR MAHESH; POKHARKAR K; WAKCHURE V
权利人:GENERICS UK LTD; GORE VINAYAK G; GADAKAR MAHESH; POKHARKAR K; WAKCHURE V
摘要:The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.

专利号:US-7825268-B2
优先权日:2003-12-23
标 题:Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
发明人：STUMPE STEFAN; BREVES ROLAND; HUCHEL URSULA; JANSSEN FRANK; HAETZELT ANDRE
权利人:HENKEL AG & CO KGAA
摘要:Compounds of the Formula I, n nwherein A 1 is O or NH; A 2 is O or S; each of R 1 and R 2 is independently hydrogen, a methyl or C 2 -C 8 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R 3 is a C 1 -C 18 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R 1 , R 2 and R 3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C 1 -C 6 -alkyl, trifluoromethyl, C 1 -C 6 -alkoxy, C 6 -C 10 -aryl, and C 1 -C 6 -alkyl-C 6 -C 10 -aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.

专利号:US-10808262-B2
优先权日:2013-12-03
标题:Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
发明人：OSTERHOUT ROBIN E; BURGARD ANTHONY P; PHARKYA PRITI; ANDRAE STEFAN
权利人:GENOMATICA INC
摘要:The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

专利号:US-3697552-A
优先权日:1961-08-18
标题 :Anthracyclidine-acetic acid derivatives
发明人：CONOVER LLOYD H; WOODWARD ROBERT B
权利人:PFIZER
摘要:The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a, 10-octahydroanthracenes comprising: (1) an aldol condensation with a glyoxalic acid ester to give a 2-carboxymethylidene3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracene ester; (2) Michael reaction of said ester with an amine to produce a 3,4,10trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracene-2-( Alpha amino)acetic acid ester; (3) conversion of the triketone to the corresponding 4,10-diketone by (a) selective reduction of the Michael reaction product to the corresponding 3-hydroxy compound, followed by conversion of the 3-hydroxy compound to the corresponding 3-formyloxy compound and removal of the 3-formyloxy group by treatment with zinc dust to give a 4,10-dioxo1,2,3,4,4a,9,9a,10-octahydroanthracene-2-( Alpha -amino)acetic acid ester; or (b) conversion of the hydrochloride salt of the Michael reaction product to a lactone by reaction with p-toluenesulfonic acid and treatment of the lactone with zinc dust formic acid; (4) conversion of the 4,10-diketo-1,2,3,4,4a,9,9a,10octahydroanthracene-2-( Alpha -amino)acetic acid to a mixed anhydride; (5) followed by acylation of a malonic acid ester with the mixed anhydride; (6) cyclization of the acyl malonate derivative to a 12a-deoxytetracycline which is then hydroxylated to a tetracycline. The preparation of the 3,4,10-trioxo1,2,3,4,4a,9,9a,10-octahydroanthracenes from benzoyl halides by (a) Friedel-Crafts reaction of a benzoyl halide with a pyrocatechol ether, e.g., a di-(lower)alkyl ether, to produce a 3,4-di-(lower)alkoxybenzophenone; (b) conversion of the benzophenone by partial or complete reduction of the carbonyl group by chemical or catalytic methods to a 3,4-di-(lower)alkoxy diphenyl methanol or 3,4-di-(lower)alkoxy diphenyl methane; or to a 3,4-di-(lower)alkoxy diphenyl alkane via a Grignard reaction and reduction of the thus-produced alkanol; (c) oxidation of the 3,4-di-(lower)alkoxy diphenyl alkane, or the corresponding dihydroxy compound, to a dienedioic acid ester or dienedioic acid; (d) hydrogenation of the dienedioic acid compound to a benzyl adipic acid derivative; (e) cyclization of said compound to a 2-(2-carbalkoxyethyl)-4-tetralone by means of dehydrating or dehydrohalogenating agents; (f) cyclization of the 4-tetralone derivatives by condensation with a dialkyloxalate to give a 2carbalkoxy 3,4,10-trioxo-octahydroanthracene; and (g) removal of the 2-substituent by decarboxylation. The intermediates and final products are useful as bactericides and/or chelating agents.

专利号:US-3829453-A
优先权日:1961-08-18
标题:Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof
发明人：CONOVER L; WOODWARD R
权利人:PFIZER
摘要:THE TOTAL SYNTHESIS OF TETRACYCLINE-TYPE ANTIBIOTICS BY A MULTI-STEP PROCESS BEGINING WITH 3,4,10-TRIOXO-1,2,3,4,4A, 9,9A,10-OCTAHYDROANTHRACENES COMPRISING: (1) AN ALDOL CONDENSATION WITH A GLYOXALIC ACID ESTER TO GIVE A 2-CARBOXYMETHYLIDENE-3,4,10-TRIOXO - 1,2,3,4,4A,9,9A,10 - OCTAHYDROANTHRACENE ESTER; (2) MICHAEL REACTION OF SAID ESTER WITH AN AMINE TO PRODUCE A 3,4,10-TRIOXO1,2,3,4,4A,9,9A, 10-OCTAHYDROANTHRACENE-2-(A-AMINO)ACETIC ACID ESTER; (3) CONVERSION OF THE TRIKETONE TO THE CORRESPONDING 4,10DIKETONE BY (A) SELECTIVE REDUCTION OF THE MICHAEL REACTION PRODUCT OF THE CORRESPONDING 3-HYDROXY COMPOUND, FOLLOWED BY CONVERSION OF THE 3-HYDROXY COMPOUND OF THE CORRESPONDING 3-FORMYLOXY COMPOUND AND REMOVAL OF THE 3-FORMYLOXY GROUP BY TREATMENT WITH ZINC DUST TO GIVE A 4,10-DIOXO- 1,2,3,4,4A,9,9A,10 -OCTAHYDROANTHRACENE-2-(AAMINO)ACETIC ACID ESTER; OR (B) CONVERSION OF THE HYDROCHLORIDE SALT OF THE MICHAEL RACTION PRODUCT TO A LACTONE BY REACTION WITH P-TOLUENE-SULFONIC ACID AND TREATMENT OF THE LACTONE WITH ZINC DUST FORMIC ACID; (4) CONVERSION OF THE 4,10-DIKETO - 1,2,3,4,4A,9,9A,10 - OCTAHYDROANTHRACENE2-(A-AMINO)ACETIC ACID TO A MIXED ANHYDRIDE; (5) FOLLOWED BY ACYLATION OF A MALONIC ACID ESTER WITH THE MIXED ANHYDRIDE; (6) CYCLIZATION OF THE ACYL MALONATE DERIVATIVE TO A 12A-DEOXYTETRACYCLINE WHICH IS THEN HYDROXYLATED TO A TETRACYCLINE. THE PREPARATION OF THE 3,4,10-TRIOXO-1,2,3,4, 4A,9,9A,10-OCTAHYDROANTHRACENES FROM BENZOLY HALIDES BY (A) FRIDEL-CRAFTS REACTION OF A BENZOYL HALIDE WITH A PYROCATECHOL ETHER, G.G., A DI(LOWER)ALKYL ETHER, TO PRODUCE A 3,4-DI-(LOWER)ALKOXYBENZOPHENONE; (B) CONVERSION OF TGE BENZOPHENONE BY PARTIAL OR COMPLETE REDUCTION OF THE CARBONYL GROUP BY CHEMICAL OR CATALYTIC METHODS TO A 3,4-DI-(LOWER)ALKOXY DIPHENYL METHANOL OR 3,4-DI(LOWER) ALKOXY DIPHENYL METHANE; OR TO A 3,4-DI(LOWER ) ALKOXY DIPHENYL ALKANE VIA A GRIGNARD REACTION AND REDUCTION OF THE THUS-PRODUCED ALKANOL; (C) OXIDATION OF THE 3,4-DI(LOWER)ALKOXY DIPHENYL ALKANE, OR THE CORRESPONDING DIHYDROXY COMPOUND, TO A DIENEDIOIC ACID ESTER OR DIENEDIOIC ACID; (D) HYDROGENATION OF THE DIENEDIOIC ACID COMPOUND TO A BENZYL ADIPIC AICD DERIVATIVE; (E) CYCLIZATION OF SAID COMPOUND TO A 2-(2-CARBALKOXYETHYL)-4-TETRALONE BY MEANS OF DEHYDRATING OR DEHYDROHALOGENATING AGENTS; (F) CYCLIZATION OF THE 4-TETRALONE DERIVATIVES BY CONDENSATION WITH A DIALKLOXALATE TO GIVE A 2-CARBALKOXY 3,4,10-TRIOXO- OCTAHYDROANTHRACENE; AND (G) REMOVAL OF THE 2-SUBSTITUENT BY DECARBOXYLATION. THE INTERMEDIATES AND FINAL PRODUCTS ARE USEFUL AS BACTERICIDES AND/OR CHELATING AGENTS.