CAS: 7499-07-2; 4-Chloro-2-Methylbenzoic Acid

该化合物是一种芳香的碳酸,其特点是含有一个氯组和一个甲基组,在苯并酸框架内,这种化合物的特点是在par 位置的氯原子和在正方形位置的甲基组,与碳苯并酸功能组相对,它一般是白色到非白色固体的,在水中容易溶解,但在乙醇和丙酮等有机溶剂中更加溶解.氯分成分的存在可以影响其再活性和极性,使其在各种化学合成和应用中有用,包括制药和农用化学品.此外,四氯-2甲基苯并呋喃可以对碳酸进行典型的反应,例如酯化和酸基反应.它的独特结构允许它参与电子嗜好替代反应,使其在有机合成中成为多用途中间体.在处理这种化合物时,应当采取安全防范措施,因为如果它可能构成健康风险,那么它也会在处理这种化合物时会对其构成安全风险.

结构式图片

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ECHA物质C&L通报

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CAS号74-88-4 碘甲烷 | CAS号74-11-3 对氯苯甲酸 | CAS号615-60-1 4-氯-1,2-二甲基苯 | CAS号124-38-9 二氧化碳 | CAS号14495-51-3 2-溴-5-氯甲苯 | CAS号50712-68-0 2-甲基-4-氯苯腈 | CAS号3274-12-2 4-甲基-4-三氯甲基-2,5... | CAS号598-30-1 仲丁基锂 | CAS号594-19-4 叔丁基锂 | CAS号321-21-1 4-氟-2-甲基苯甲酸 | CAS号21900-44-7 4-chloro-2-meth... | CAS号190367-50-1 methyl 4-fluoro... | CAS号190368-28-6 methyl 4-amino-... | CAS号89-20-3 4-氯邻苯二酸 | CAS号75319-02-7 4-氯-2-甲基苯甲酰肼 | CAS号145908-29-8 2-溴甲基-5-氯苯甲酸甲酯 | CAS号129716-11-6 4-氯-2-甲基苄醇 | CAS号176644-45-4 2,3-dimethyl-5-... | CAS号37074-38-7 1-(4-氯-2-甲基苯基)乙酮

合成工艺路线路线简述

    4-甲基-4-(三氯甲基)环己-2,5-二烯-1-酮置于ppa体系中,化学反应生成 4-氯-2-甲基苯甲酸
    参考文献:Rearrangement Of 4-Methyl-4-Trichloromethyl-2,5-Cyclohexadienols1,2
    标题:Rearrangement Of 4-Methyl-4-Trichloromethyl-2,5-Cyclohexadienols1,2
    摘要:
    DOI:10.1021/ja01533A030

    海关参考信息

    专利信息


    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11034690-B2
    优先权日:2016-11-11
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-9809591-B2
    优先权日:2011-03-08
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
    权利人:3-V BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries
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    主要参考文献

    参考标题:Brønsted Acid Catalyzed Dearomatization By Intramolecular Hydroalkoxylation/claisen Rearrangement: Diastereo‐ And Enantioselective Synthesis Of Spirolactams
    作者:Peng‐fei Chen,Bo Zhou,Peng Wu,Binju Wang,Long‐wu Ye |发布日期:2021.12.20
    摘要:A Brønsted Acid Catalyzed Intramolecular Hydroalkoxylation/claisen Rearrangement Is Disclosed That Involves An Unexpected Dearomatization Of Nonactivated Arenes And Heteroaromatic Compounds And Allows The Practical And Atom-Economic Synthesis Of Various Valuable Spirolactams. Moreover, The Asymmetric Version Of This Tandem Cyclization Is Also Achieved Via Kinetic Resolution By Chiral Phosphoric Acid

    合成参考文献


    摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 139.
    摘要:D. Peltier, C. R. Acad. Sci., Ser. C 241, 1467 (1955).
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