4-甲基-4-(三氯甲基)环己-2,5-二烯-1-酮置于ppa体系中,化学反应生成 4-氯-2-甲基苯甲酸 参考文献:Rearrangement Of 4-Methyl-4-Trichloromethyl-2,5-Cyclohexadienols1,2 标题:Rearrangement Of 4-Methyl-4-Trichloromethyl-2,5-Cyclohexadienols1,2 摘要: DOI:10.1021/ja01533A030
专利号:US-2024400552-A1 优先权日:2016-11-11 标题 :Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-11622968-B2 优先权日:2011-03-08 标 题:Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-11034690-B2 优先权日:2016-11-11 标 题:Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-9809591-B2 优先权日:2011-03-08 标题 :Heterocyclic modulators of lipid synthesis 发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W 权利人:3-V BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
参考标题:Brønsted Acid Catalyzed Dearomatization By Intramolecular Hydroalkoxylation/claisen Rearrangement: Diastereo‐ And Enantioselective Synthesis Of Spirolactams 作者:Peng‐fei Chen,Bo Zhou,Peng Wu,Binju Wang,Long‐wu Ye |发布日期:2021.12.20 摘要:A Brønsted Acid Catalyzed Intramolecular Hydroalkoxylation/claisen Rearrangement Is Disclosed That Involves An Unexpected Dearomatization Of Nonactivated Arenes And Heteroaromatic Compounds And Allows The Practical And Atom-Economic Synthesis Of Various Valuable Spirolactams. Moreover, The Asymmetric Version Of This Tandem Cyclization Is Also Achieved Via Kinetic Resolution By Chiral Phosphoric Acid
合成参考文献
摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 139. 摘要:D. Peltier, C. R. Acad. Sci., Ser. C 241, 1467 (1955).