CAS: 78162-58-0; N,N-Dimethyl-1H-Imidazole-1-Sulfonamide

相似化合物

135773-25-0 140174-48-7 1349716-00-2

上下游产品

CAS号288-32-4 咪唑 | CAS号13360-57-1 二甲基胺磺酰氯 | CAS号124-40-3 二甲胺 | CAS号489471-57-0 1-((1H-咪唑-1-基)磺... | CAS号129378-52-5 2-(叔丁基二甲基甲硅烷基)-... | CAS号14062-78-3 N,N-二甲基-4-甲基苯甲酰胺 | CAS号611-74-5 N,N-二甲基苯甲酰胺 | CAS号24167-52-0 3-氯-N,N-二甲基苯甲酰胺 | CAS号30086-17-0 4-氟-1H-咪唑 | CAS号54925-64-3 氮-叔丁基二甲基硅基咪唑 | CAS号129378-52-5 2-(叔丁基二甲基甲硅烷基)-... | CAS号14062-80-7 N,N-二甲基4-氯苯甲酰胺 | CAS号13577-85-0 N,N-dimethylnap... | CAS号123914-19-2 N,N-dimethyl-2-... | CAS号7291-01-2 Benzamide, N,N-...

2-[二甲基(2-甲基-2-丙基)甲硅烷基]-N,N-二甲基-1H-咪唑-1-磺酰胺置于四丁基氟化铵体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.5H,反应生成 N,N-二甲基咪唑-1-磺酰胺
参考文献:Ngochindo,Raphael I.,Journal Of The Chemical Society. Perkin Transactions I,1990,# 6,P. 1645-1648
标题:Ngochindo,Raphael I.,Journal Of The Chemical Society. Perkin Transactions I,1990,# 6,P. 1645-1648

专利信息

专利号:US-5359051-A
优先权日:1990-01-11
标题 :Compounds useful in the synthesis of nucleic acids capable of cleaning RNA
发明人：COOK PHILLIP D; GUINOSSO CHARLES J; BRUICE THOMAS
权利人:ISIS PHARMACEUTICALS INC
摘要:Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. In preferred embodiments, the reactive portions comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with and without intervening intercalating moieties and act through phosphorodiester hydrolytic bond cleavage. Therapeutics, diagnostics and research methods are also disclosed. Synthetic nucleosides and nucleoside fragments are also provided which are useful for elaboration of oligonucleotides for such purposes.

专利号:US-2009118512-A1
优先权日:2006-03-31
标 题:Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One
发明人：MARTIN PIERRE; BOUDIER ANDREAS; QUIRMBACH MICHAEL; MAH ROBERT; JOTTERAND NATHALIE
权利人:MARTIN PIERRE; BOUDIER ANDREAS; QUIRMBACH MICHAEL; MAH ROBERT; JOTTERAND NATHALIE
摘要:6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.

专利号:WO-9506037-A1
优先权日:1993-08-27
标题 :New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
发明人：VOLLINGA ROELANT CHRISTIAAN; MENGE WIRO MICHAEL PETRUS BERN; TIMMERMAN HENDRIK
权利人:VRIJE UNIVERSITEIT; VOLLINGA ROELANT CHRISTIAAN; MENGE WIRO MICHAEL PETRUS BERN; TIMMERMAN HENDRIK
摘要:The invention relates to new imidazole derivatives of formula (I) having agonistic and antagonistic activity on the histamine H3-receptor. More in particular the invention concerns 4- and 5-substituted aminoalkyl imidazoles and their derivatives. The invention further relates to the synthesis of these compounds, pharmaceutical compositions comprising the said compounds or pharmacological salts thereof, and the use of the compounds as agents having biological activity on the histamine H3-receptor or for the preparation of a pharmaceutical composition.

专利号:CN-104507928-A
优先权日:2012-07-03
标 题:Heterocyclic regulators of lipid synthesis

专利号:KR-20160100329-A
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CN-106061963-A
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof