2,6-二甲基苯胺 以89%的收率获得2,6-二甲基氯代乙酰苯胺 参考文献:Acetamides And Benzamides That Are Useful In Treating Sexual Dysfunction 标题:Acetamides And Benzamides That Are Useful In Treating Sexual Dysfunction 摘要:本发明涉及使用式(I)的化合物治疗性功能障碍,以及含有式(I)化合物的组合物用于治疗性功能障碍.
专利号:US-2023173450-A1 优先权日:2020-04-28 标题:Automated chemical synthesis platform 发明人:CRONIN LEROY; MEHR HESSAM; CRAVEN MATTHEW; LEONOV ARTEM 权利人:UNIV GLASGOW COURT 摘要:The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.
专利号:ES-2643064-T3 优先权日:2014-04-23 标 题:Method for the synthesis of clofarabine
专利号:RU-2042662-C1 优先权日:1992-06-09 标题:Method of synthesis of n-(chloroacetyl)-2,6-dimethylaniline
专利号:US-2009306429-A1 优先权日:2004-12-06 标 题 :Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of a quaternary ammonium salt 发明人:JANMEJAY RAJNIKANT VYAS; SHAH JAYSHREE H; RAVAL RAVINDRA NIRANJANBHAI 权利人:JANMEJAY RAJNIKANT VYAS; SHAH JAYSHREE H; RAVAL RAVINDRA NIRANJANBHAI 摘要:The invention relates to a process for the preparation of a quaternary ammonium hydroxide, in particular denatonium hydroxide, and the use thereof for the preparation of a quaternary ammonium salt, in particular of denatonium benzoate or a denatonium fatty acid derivative. Due to its extremely bitter taste, this latter compound is applied in the art as an aversive agent, biocide, antifoulant and flavorant. It is usually prepared from a quaternary ammonium halide in an organic environment, which after isolation and purification is converted to a hygroscopic and unstable hydroxide intermediate, which in turn is immediately converted to the salt of interest in the solvent in which it is prepared. It is now found that these isolation steps can be avoided by performing the reaction at aqueous conditions. This is more straightforwardly and does not require costly precautions to avoid contact while handling. Moreover, the process of the invention allows to produce the quaternary ammonium salt from a lignocaine compound in a one-pot synthesis involving mostly water.
参考标题:Synthesis Of Ranolazine Metabolites And Their Anti-Myocardial Ischemia Activities 作者:Zhangyu Yao,Shubo Gong,Teng Guan,Yunman Li,Xiaoming Wu,Hongbin Sun 摘要:The Anti-Anginal Drug Ranolazine, A Partial Fatty Acid Oxidation (Pfox) Inhibitor, Is Thought To Modulate The Metabolism During Myocardial Ischemia By Activating Pyruvate Dehydrogenase Activity To Promote Glucose Oxidation. Ranolazine And Its Five Principal Metabolites: Cvt-2512, Cvt-2513, Cvt-2514, Cvt-2738 And Cvt-4786, Were Synthesized. The Effect Of Ranolazine And Its Metabolites On The Ecg (Electrocardiogram) Of Mice With Myocardial Ischemia Induced By Isoprenaline And Their Effect On Alleviating The Symptom Of Myocardial Ischemia Were Tested And Compared. The Results Showed That Cvt-2738 And Cvt-2513 Could Be Protective Against Mice Myocardial Ischemia Induced By Isoprenaline. Within All The Metabolites Tested In This Study, Cvt-2738 Exhibited The Best Potency, However, It Was Still Less Potent Than Ranolazine.
合成参考文献
参考文献:10.1007/s11030-021-10374-5 摘要:Suryawanshi MR, Kanhed AM, Kulkarni VM, Bhosale SH, Yadav MR. Design, synthesis, and computational studies of phenylacetamides as antidepressant agents. Molecular Diversity. 2022 Feb 07;26(6):3157–72. doi: 10.1007/s11030-021-10374-5. 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003). 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003). 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2006). 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).