相似化合物
88491-61-6 1196155-35-7 1353854-35-9欧盟法规
ECHA物质C&L通报上下游产品
CAS号123-33-1 马来酰肼 | CAS号502-95-4 四氢-3,6-吡嗪二酮 | CAS号88497-27-2 6-溴-3-吡嗪胺 | CAS号135034-10-5 3-氯-6-碘哒嗪 | CAS号17321-29-8 3-溴-6-甲氧基哒嗪 | CAS号695184-05-5 4-(6-Bromopyrid...合成工艺路线路线简述
- 合成目标产物 3,6-Dibromopyridazide 主要起始原料 Maleic Hydrazide
- (文献来源)合成步骤主要原料 Maleic Hydrazide
抑芽丹置于三溴氧磷体系中,用 Neat (No Solvent) 用作溶剂,化学反应 3.0H,以80%的收率获得3,6-二溴哒嗪
参考文献:哒嗪氮氧化物作为活性氧的光活化替代物
标题:哒嗪氮氧化物作为活性氧的光活化替代物
摘要:开发了一种从哒嗪n-氧化物光诱导析出原子氧的方法.这种尚未开发的氧同素异形体介导复杂的多功能分子内的芳烃 C-H 氧化.还开发了一种水溶性哒嗪n-氧化物,并显示其可促进水溶液中的光诱导 Dna 裂解.总而言之,这些研究强调了哒嗪n-氧化物作为可光活化的 O( 3 P) 前体在有机合成和化学生物学中的应用.
Doi:10.1021/acs.Orglett.2C00227
专利信息
专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人:OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
专利号:CN-118955404-A
优先权日:2024-07-30
标题:Synthesis method of compound 3, 5-dibromopyridazine
专利号:CN-112300057-B
优先权日:2020-10-19
标 题 :A kind of D-A-D hole transport material and its synthesis method and application