CAS: 2268-05-5; 2,6-Dichlorofluorobenzene

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CAS号19393-92-1 1-溴-2,6-二氯苯 | CAS号87-61-6 1,2,3-三氯苯 | CAS号608-31-1 2,6-二氯苯胺 | CAS号1092485-88-5 3,5-二氯-4-氟苯硼酸频哪醇酯 | CAS号3862-73-5 2,3,4-三氟苯胺 | CAS号367-22-6 4-氯-3-氟苯胺 | CAS号393-79-3 2,4-二氯-3-氟硝基苯 | CAS号443-93-6 2，4-二氯-3-氟苯胺 | CAS号2822-41-5 2,3,4-三氟苯酚 | CAS号771-69-7 2,3,4-三氟硝基苯 | CAS号322-26-9 2-(2,3,4-triflu... | CAS号202982-67-0 4-氯-3-氟碘苯

2,3-二氯硝基苯置于potassium Fluoride,氯体系中,化学反应 3.0H,反应生成2,6-二氯氟苯
参考文献:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
标题:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
摘要:本发明涉及医药中间体的制备方法领域,特别是涉及喹诺酮类药物关键中间体的制备方法领域,开发了一种以邻二氯苯为原料联产喹诺酮类药物关键中间体的方法.本发明方法以邻二氯苯为原料,硝化后经精馏提纯再分步结晶得到2,3-二氯硝基苯和3,4-二氯硝基苯.2,3-二氯硝基苯经氟化反应得到2-氟-3-氯硝基苯,然后氯化得到2,6-二氯氟苯,再硝化得到2,4-二氯-3-氟硝基苯,最后氟化得到2,3,4-三氟硝基苯.3,4-二氯硝基苯经氟化反应得到4-氟-3-氯硝基苯,然后氯化得到2,4-二氯氟苯,最后与乙酰氯发生酰化反应得到2,4-二氯-5-氟苯乙酮.

专利信息

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9718764-B2
优先权日:2013-03-22
标题:Synthetic building blocks for the production of materials for organic electroluminescence devices
发明人：STOESSEL PHILIPP; PARHAM AMIR HOSSAIN; JATSCH ANJA
权利人:MERCK PATENT GMBH
摘要:The present invention relates to compounds which are suitable as synthesis precursors for the production of electronically active materials for use in organic electroluminescence devices.

专利号:CN-117486670-B
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorobromobenzene

专利号:CN-118637975-A
优先权日:2024-08-13
标 题:Synthesis method of 3,4, 5-trifluoro-bromobenzene

专利号:CN-117486670-A
优先权日:2023-12-29
标 题:A kind of synthesis method of 3,4,5-trifluorobromobenzene