CAS: 2923-56-0; (4-(Trifluoromethyl)Phenyl)Hydrazine Hydrochloride

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CAS号455-14-1 4-氨基三氟甲苯 | CAS号641639-55-6 5-(4-甲基硫烷基苯基)-1... | CAS号19735-44-5 2,3,4,5-四氢-8-(三... | CAS号81558-19-2 2,3-二甲基-5-(三氟甲基...

对三氟甲基苯胺置于盐酸,Sodium Nitrite,Tin(II) Chloride Dihdyrate体系中,用 水 用作溶剂,化学反应 3.0H,反应生成4-三氟甲基苯肼盐酸盐
参考文献:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
标题:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
摘要:一系列新型 2,6-二甲基-4-氨基嘧啶腙5被合理设计和合成为丙酮酸脱氢酶复合物 E1 (Pdhc-E1) 抑制剂.化合物5强烈抑制大肠杆菌(e.Coli)pdhc-E1(ic 50值为 0.94-15.80 μm).分子对接,定点诱变,酶促和抑制动力学分析表明,化合物5竞争性抑制 Pdhc-E1 并以"直线"模式结合在大肠杆菌pdhc-E1 活性位点,这是一种新的结合模式. 在体外抗真菌试验中,大多数化合物5在50μg/ Ml的显示针对六个测试植物病原性真菌,包括菌丝生长超过80%的抑制灰霉病,念珠菌fructigena,炭疽病菌,和葡萄座腔dothidea侵染.值得注意的是,5F和5I对m. Fructigena 的效力是商业杀菌剂克菌丹和百菌清的1.8-380 倍.在体内,与商业杀菌剂戊唑醇相比,5F和5I控制m. Fructigena的生长.因此,5F和5I对防治果蝇桃褐腐病具有潜在的商业价值.
Doi:10.1021/acs.Jafc.0C07701

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-7442802-B2
优先权日:2002-06-27
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:CN-118048634-A
优先权日:2023-09-12
标题:A method for electrochemical synthesis of sulfoximine N-H aromatic acylated derivatives

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:CN-113774411-A
优先权日:2021-09-22
标题 :A kind of method for electrochemical synthesis of aryl-substituted quinoxaline (ketone) derivatives

专利号:CN-120060869-A
优先权日:2025-03-20
标题:A method for electrocatalytic synthesis of aryl sulfone compounds